Real-time detection of influenza A virus using semiconductor nanophotonics

Dominic Lepage; Alvaro Jiménez; Jacques Beauvais; Jan J Dubowski

doi:10.1038/lsa.2013.18

Go to Nature Website

Your Location：

Home >

Browse articles >

Real-time detection of influenza A virus using semiconductor nanophotonics

Original Articles

- Real-time detection of influenza A virus using semiconductor nanophotonics
- Light: Science & Applications Vol. 2, Issue 1-2, (2013)
- Affiliations：
  
  Laboratory for Quantum Semiconductors and Photon-based BioNanotechnology, Interdisciplinary Institute for Technological Innovation (3IT), Department of Electrical and Computer Engineering, Universite´ de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada
- Author bio：
  
  Professor JJ Dubowski, Laboratory for Quantum Semiconductors and Photon-based BioNanotechnology, Interdisciplinary Institute for Technological Innovation (3IT), Department of Electrical and Computer Engineering, Universite´ de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada Email: jan.j.dubowski@usherbrooke.ca
- Funds：
- DOI：10.1038/lsa.2013.18
  CLC：
- Published：2013-06，
  
  Published Online：12 April 2013，
  
  Received：04 June 2012，
  
  Revised：23 December 2012，
  
  Accepted：24 December 2012
- Accepted：
Scan QR Code
Lepage, D. et al. Real-time detection of influenza A virus using semiconductor nanophotonics. Light: Science & Applications, 2, e62 (2013).
DOI：

Lepage, D. et al. Real-time detection of influenza A virus using semiconductor nanophotonics. Light: Science & Applications, 2, e62 (2013). DOI： 10.1038/lsa.2013.18.

摘要

Abstract

Modern miniaturization and the digitalization of characterization instruments greatly facilitate the diffusion of technological advances in new fields and generate innovative applications. The concept of a portable

inexpensive and semi-automated biosensing platform

or lab-on-a-chip

is a vision shared by many researchers and venture industries. Under this scope

we present a semiconductor monolithic integration approach to conduct surface plasmon resonance studies. This technology is already commonly used for biochemical characterization in pharmaceutical industries

but we have reduced the technological platform to a few nanometers in scale on a semiconductor chip. We evaluate the signal quality of this nanophotonic device using hyperspectral-imaging technology

and we compare its performance with that of a standard prism-based commercial system. Two standard biochemical agents are employed for this characterization study: bovine serum albumin and inactivated influenza A virus. Time resolutions of data acquisition varying between 360 and 2.2 s are presented

yielding 2.7×10

−5

–1.5×10

−6

RIU resolutions

respectively.

关键词

Keywords

GaAs/AlGaAs quantum well devicehyperspectral imaging technologyinfluenza A virusintegrated surface plasmon resonance biosensor

references

Marescaux J, Leroy J, Gagner M, Rubino F, Mutter Det al. Transatlantic robot-assisted telesurgery.Nature2001;413: 379–380..

Tseng D, Mudanyali O, Oztoprak C, Isikman SO, Sencan Iet al. Lensfree microscopy on a cellphone.Lab Chip2010;10: 1787–1792..

Lee SJ, Lee SY. Micro total analysis system (mu-TAS) in biotechnology.Appl Microbiol Biotechnol2004;64: 289–299..

Raether H. Surface-plasmons on smooth and rough surfaces and on gratings.Springer Tracts Mod Phys1988;111: 1–133..

Schasfoort RB, Tudos AJ.Handbook of Surface Plasmon Resonance. Cambridge: Royal Society of Chemistry, 2008.

Kabashin AV, Evans P, Pastkovsky S, Hendren W, Wurtz GAet al. Plasmonic nanorod metamaterials for biosensing.Nat Mater2009;8: 867–871..

de Bruijn HE, Kooyman RP, Greve J. Surface plasmon resonance microscopy: improvement of the resolution by rotation of the object.Appl Opt1993;32: 2426–2430..

Rothenhausler B, Knoll W. Surface-plasmon microscopy.Nature1988;332: 615–617..

Lepage D, Jiménez A, Carrier D, Beauvais J, Dubowski JJ. Conic hyperspectral dispersion mapping applied to semiconductor plasmonics.Light Sci Appl2012;1: e28..

Duplan V, Miron Y, Frost E, Grandbois M, Dubowski JJ. Specific immobilization of influenza A virus on GaAs (001) surface.J Biomed Opt2009;14: 054042–054046..

Hassen WM, Duplan V, Frost E, Dubowski JJ. Quantitation of influenza A virus in the presence of extraneous protein using electrochemical impedance spectroscopy.Electrochim Acta2011;56: 8325–8328..

Romanato F, Lee KH, Kang HK, Ruffato G, Wong CC. Sensitivity enhancement in grating coupled surface plasmon resonance by azimuthal control.Opt Express2009;17: 12145–12154..

Lepage D, Jiménez A, Carrier D, Beauvais J, Dubowski JJ. Hyperspectral imaging of diffracted surface plasmons.Opt Express2010;18: 27327–27335..

Glytsis EN, Gaylord TK. Rigorous 3-D coupled wave diffraction analysis of multiple superposed gratings in anisotropic media.Appl Opt1989;28: 2401–2421..

Lepage D, Dubowski JJ. Surface plasmon effects induced by uncollimated emission of semiconductor microstructures.Opt Express2009;17: 10411–10418..

Lepage D, Carrier D, Jimenez A, Beauvais J, Dubowski JJ. Plasmonic propagations distances for interferometric surface plasmon resonance biosensing.Nanoscale Res Lett2011;6: 388..

Jimenez A, Lepage D, Beauvais J, Dubowski JJ. Study of surface morphology and refractive index of dielectric and metallic films used for the fabrication of monolithically integrated surface plasmon resonance biosensing devices.Microelectron Eng2012;93: 91–94..

NanoSPR. Available athttp://www.nanospr.comhttp://www.nanospr.com, 2012.

Das M, Hohertz D, Nirvan R, Brolo AG, Kavanagh KLet al. Improved performance of nanohole surface plasmon resonance sensors by the integrated response method.IEEE Photon J2011;3: 441–449..

Stewart ME, Yao JM, Maria J, Gray SK, Rogers JAet al. Multispectral thinfilm biosensing and quantitative imaging using 3D plasmonic crystals.Anal Chem2009;81: 5980–5989..

Hoa XD, Kirk AG, Tabrizian M. Enhanced SPR response from patterned immobilization of surface bioreceptors on nano-gratings.Biosensors Bioelectron2009;24: 3043–3048..

Azzam RM, Rigby PG, Krueger JA. Kinetics of protein adsorption and immunological reactions at a liquid/solid interface by ellipsometry.Phys Med Biol1977;22: 422..

Tencer M, Charbonneau R, Lahoud N, Berini P. AFM study of BSA adlayers on Au stripes.Appl Surf Sci2007;253: 9209–9214..

Akimoto T, Sasaki S, Ikebukuro K, Karube I. Refractive-index and thickness sensitivity in surface plasmon resonance spectroscopy.Appl Opt1999;38: 4058–4064..

Barer R, Tkaczyk S. Refractive index of concentrated protein solutions.Nature1954;173: 821–822..

Ioseliani OR.Focus on Eye Research. New York: Nova Science Publishers, 2006.

Hoa XD, Kirk AG, Tabrizian M. Towards integrated and sensitive surface plasmon resonance biosensors: a review of recent progress.Biosensors Bioelectron2007;23: 151–160..

Huang Y, Ho HP, Kong SK, Kabashin AV. Phase-sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications.Ann Phys (Berlin)2012;524: 637–662..

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰