Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography

Xosé Luís Deán-Ben; Daniel Razansky

doi:10.1038/lsa.2014.18

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Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography

Original Articles

- Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography
- Light: Science & Applications Vol. 3, Issue 1, (2014)
- Affiliations：
  
  Institute for Biological and Medical Imaging (IBMI), Technical University of Munich and Helmholtz Center Munich, 85764 Neuherberg, Germany
- Author bio：
  
  Dr D Razansky, Institute for Biological and Medical Imaging (IBMI), Technical University of Munich and Helmholtz Center Munich, Ingolstädter Landstrabe 1, 85764 Neuherberg, Germany E-mail: dr@tum.de
- Funds：
- DOI：10.1038/lsa.2014.18
  CLC：
- Published：2014-03，
  
  Published Online：31 January 2014，
  
  Received：10 May 2013，
  
  Revised：24 September 2013，
  
  Accepted：27 September 2013
- Accepted：
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Deán-Ben, X. L. & Razansky, D. Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography. Light: Science & Applications, 3, e137 (2014).
DOI：

Deán-Ben, X. L. & Razansky, D. Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography. Light: Science & Applications, 3, e137 (2014). DOI： 10.1038/lsa.2014.18.

摘要

Abstract

Optoacoustics provides a unique set of capabilities for bioimaging

associated with the intrinsic combination of ultrasound- and light-related advantages

such as high spatial and temporal resolution as well as powerful spectrally enriched imaging contrast in biological tissues. We demonstrate here

for the first time

the acquisition

processing and visualization of five-dimensional optoacoustic data

thus offering unparallel imaging capacities among the current bioimaging modalities. The newly discovered performance is enabled by simultaneous volume

tric detection and processing of multispectral data and is further showcased here by attaining time-resolved volumetric blood oxygenation maps in deep human vessels and real-time tracking of contrast agent distribution in a murine model

in vivo

关键词

Keywords

biophotonicsmultispectraloptoacoustic imagingphotoacoustic tomography

references

Tainter CS, Bell AG. Selenium and the photophone.Nature1880;22: 500–503..

Wang LV.Photoacoustic Imaging and Spectroscopy. Boca Raton, FL: CRC Press; 2009.

Razansky D, Distel M, Vinegoni C, Ma R, Perrimon Net al. Multispectral opto-acoustic tomography of deep-seated fluorescent proteinsin vivo.Nat Photon2009;3: 412–417..

Wang LV. Multiscale photoacoustic microscopy and computed tomography.Nat Photon2009;3: 503–509..

de la Zerda A, Zavaleta C, Keren S, Vaithilingam S, Bodapati Set al. Carbon nanotubes as photoacoustic molecular imaging agents in living mice.Nat Nanotechnol2008;3: 557–562..

Yang JM, Favazza C, Chen R, Yao J, Cai Xet al. Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organsin vivo.Nat Med2012;18: 1297–1302..

Kim JW, Galanzha EI, Shashkov EV, Moon HM, Zharov VP. Golden carbon nanotubes as multimodal photoacousticand photothermal high-contrast molecular agents.Nat Nanotechnol2009;4: 688–694..

Ma R, Sontges S, Shoham S, Ntziachristos V, Razansky D. Fast scanning coaxial optoacoustic microscopy.Biomed Opt Express2012;3: 1724–1731..

Zhang HF, Maslov K, Stoica G, Wang LH. Functional photoacoustic microscopy for high-resolution and noninvasivein vivoimaging.Nat Biotechnol2006;24: 848–851..

Yao JJ, Maslov KI, Zhang Y, Xia YN, Wang LV. Label-free oxygen-metabolic photoacoustic microscopyin vivo.J Biomed Opt2011;16: 076003..

Beard P. Biomedical photoacoustic imaging.Interface Focus2011;1: 602–631..

Brecht HP, Su R, Fronheiser M, Ermilov SA, Conjusteau Aet al. Whole-body three-dimensional optoacoustic tomography system for small animals.J Biomed Opt2009;14: 064007..

Razansky D, Buehler A, Ntziachristos V. Volumetric real-time multispectral optoacoustic tomography of biomarkers.Nat Protoc2011;6: 1121–1129..

Taruttis A, Morscher S, Burton NC, Razansky D, Ntziachristos V. Fast multispectral optoacoustic tomography (MSOT) for dynamic imaging of pharmacokinetics and biodistribution in multiple organs.PLoS ONE2012;7: e30491..

Buehler A, Herzog E, Ale A, Smith BD, Ntziachristos Vet al. High resolution tumor targeting in living mice by means of multispectral optoacoustic tomography.EJNMMI Res2012;2: 14..

Queiros D, Dean-Ben XL, Buehler A, Razansky D, Rosenthal Aet al. Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography.J Biomed Opt2013;18: 76014..

Buehler A, Dean-Ben XL, Claussen J, Ntziachristos V, Razansky D. Three-dimensional optoacoustic tomography at video rate.Opt Express2012;20: 22712–22719..

Xiang LZ, Wang B, Ji LJ, Jiang HB. 4-D photoacoustic tomography.Sci Rep2013;3: 1113..

Ntziachristos V, Razansky D. Molecular imaging by means of multispectral optoacoustic tomography (MSOT).Chem Rev2010;110: 2783–2794..

Heijblom M, Piras D, Xia W, van Hespen JC, Klaase JMet al. Visualizing breast cancer using the Twente photoacoustic mammoscope: what do we learn from twelve new patient measurements?Opt Express2012;20: 11582–11597..

Galanzha EI, Shashkov EV, Kelly T, Kim JW, Yang LLet al.In vivomagnetic enrichment and multiplex photoacoustic detection of circulating tumour cells.Nat Nanotechnol2009;4: 855–860..

Wang LD, Maslov K, Wang LH. Single-cell label-free photoacoustic flowoxigraphyin vivo.Proc Natl Acad Sci USA2013;110: 5759–5764..

Deán-Ben XL, Razansky D. Portable spherical array probe for volumetric realtime optoacoustic imaging at centimetre-scale depths.Opt Express2013;21: 28062–28071..

Dean-Ben XL, Buehler A, Ntziachristos V, Razansky D. Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography.IEEE Trans Med Imaging2012;31: 1922–1928..

American National Standards for the Safe Use of Lasers ANSI Z136.1. Orlando, FL: American Laser Institute; 2000.

Razansky D, Baeten J, Ntziachristos V. Sensitivity of molecular target detection by multispectral optoacoustic tomography (MSOT).Med Phys2009;36: 939–945..

Kim C, Favazza C, Wang LH.In vivophotoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths.Chem Rev2010;110: 2756–2782..

Lutzweiler C, Razansky D. Optoacoustic imaging and tomography: reconstruction approaches and outstanding challenges in image performance and quantification.Sensors2013;13: 7345–7384..

Cox B, Laufer JG, Arridge SR, Beard PC. Quantitative spectroscopic photoacoustic imaging: a review.J Biomed Opt2012;17: 061202..

Wang LV. Tutorial on photoacoustic microscopy and computed tomography.IEEE J Sel Top Quant2008;14: 171–179..

Jose J, Willemink RG, Steenbergen W, Slump CH, van Leeuwen TGet al. Speed-of-sound compensated photoacoustic tomography for accurate imaging.Med Phys2012;39: 7262–7271..

Huang C, Wang K, Nie LM, Wang LH, Anastasio MA. Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media.IEEE Trans Med Imaging2013;32: 1097–1110..

Dean-Ben XL, Ntziachristos V, Razansky D. Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers.J Biomed Opt2012;17: 110504..

Dean-Ben XL,Razansky D, Ntziachristos V. The effects of acoustic attenuation in optoacoustic signals.Phys Med Biol2011;56: 6129–6148..

Wang K, Ermilov SA, Su R, Brecht HP, Oraevsky AAet al. An imaging model incorporating ultrasonic transducer properties for three-dimensional optoacoustic tomography.IEEE Trans Med Imaging2011;30: 203–214..

Caballero MA, Rosenthal A, Buehler A, Razansky D, Ntziachristos V. Optoacoustic determination of spatio-temporal responses of ultrasound sensors.IEEE Trans Ultrason Ferroelectr Freq Control2013;60: 1234–1244..

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