Ultrastable embedded surface plasmon confocal interferometry

Suejit Pechprasarn; Bei Zhang; Darren Albutt; Jing Zhang; Michael Somekh

doi:10.1038/lsa.2014.68

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Ultrastable embedded surface plasmon confocal interferometry

Original Articles

- Ultrastable embedded surface plasmon confocal interferometry
- Light: Science & Applications Vol. 3, Issue 3, (2014)
- Affiliations：
  
  1.Institute of Biophysics Imaging and Optical Science (IBIOS), Life Sciences Building University of Nottingham, Nottingham NG7 2RD, UK
  2.Department of Electronic and Information Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong, China
- Author bio：
  
  Professor M Somekh, Department of Electronic and Information Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong, China E-mail: mike.somekh@nottingham.ac.uk or mike.somekh@polyu.edu.hk
- Funds：
- DOI：10.1038/lsa.2014.68
  CLC：
- Published：2014-09，
  
  Published Online：04 July 2014，
  
  Received：28 November 2013，
  
  Revised：09 April 2014，
  
  Accepted：12 April 2014
- Accepted：
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Pechprasarn, S. et al. Ultrastable embedded surface plasmon confocal interferometry. Light: Science & Applications, 3, e187 (2014).
DOI：

Pechprasarn, S. et al. Ultrastable embedded surface plasmon confocal interferometry. Light: Science & Applications, 3, e187 (2014). DOI： 10.1038/lsa.2014.68.

摘要

Abstract

As disease diagnosis becomes more sophisticated

there is a requirement to measure small numbers of molecules attached to

for instance

an antibody. This requires a sensor capable not only of high sensitivity but also the ability to make measurements over a highly localized region. In previous publications

we have shown how a modified confocal microscope allows one to make localized surface plasmon (SP) measurements on a scale far smaller than the surface plasmon propagation distance. The present implementation presents a new ultrastable interferometer system

which greatly improves the noise performance. Hitherto

we have used the central part of the back focal plane to form a reference beam with the reradiated surface plasmons. In the current system

we block the central part and use the spatial light modulator to deflect

-polarized light into the pinhole to form an interference signal with the surface plasmons

thus creating an ultrastable interferometer formed with two beams incident at very similar angles. We demonstrate the superior noise performance of the system in hostile environments and examine further adaptations of the system to further enhance noise performance.

关键词

Keywords

biosensorcommon pathconfocal microscopyinterferometrysurface plasmon

references

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