Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy

Min Gu; Hongchun Bao; Xiaosong Gan; Nicholas Stokes; Jingzhi Wu

doi:10.1038/lsa.2014.7

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Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy

Original Articles

- Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy
- Light: Science & Applications Vol. 3, Issue 1, (2014)
- Affiliations：
  
  Centre for Micro-Photonics, Faculty of Engineering & Industrial Sciences, Swinburne University of Technology, Hawthorn, Vic. 3122, Australia
- Author bio：
  
  Dr M Gu, Centre for Micro-Photonics, Faculty of Engineering & Industrial Sciences, Swinburne University of Technology, Hawthorn, Vic. 3122, Australia Email: mgu@swin.edu.au
- Funds：
- DOI：10.1038/lsa.2014.7
  CLC：
- Published：2014-03，
  
  Published Online：03 January 2014，
  
  Received：18 April 2013，
  
  Revised：24 July 2013，
  
  Accepted：29 August 2013
- Accepted：
Scan QR Code
Gu, M. et al. Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy. Light: Science & Applications, 3, e126 (2014).
DOI：

Gu, M. et al. Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy. Light: Science & Applications, 3, e126 (2014). DOI： 10.1038/lsa.2014.7.

摘要

Abstract

The precise control and manipulation of micro- and nanoparticles using an optical endoscope are potentially important in biomedical studies

bedside diagnosis and treatment in an aquatic internal organ environment

but they have not yet been achieved. Here

for the first time

we demonstrate optical nonlinear endoscopic tweezers (ONETs) for directly controlling and manipulating aquatic micro- and nanobeads as well as gold nanorods. It is found that two-photon absorption can enhance the trapping force on fluorescent nanobeads by up to four orders of magnitude compared with dielectric nanobeads of the same size. More importantly

two-photon excitation leads to a plasmon-mediated optothermal attracting force on nanorods

which can extend far beyond the focal spot. This new phenomenon facilitates a snowball effect that allows the fast uploading of nanorods to a targeted cell followed by thermal treatment within 1 min. As two-photon absorption allows an operation wavelength at the center of the transmission window of human tissue

our work demonstrates that ONET is potentially an unprecedented tool for precisely specifying the location and dosage of drug particles and for rapidly uploading metallic nanoparticles to individual cancer cells for treatment.

关键词

Keywords

endoscopygold nanorodsmicro/nanotweezingtwo-photon absorption

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