Bioinspired optical antennas: gold plant viruses

SoonGweon Hong; Mi Yeon Lee; Andrew O Jackson; Luke P Lee

doi:10.1038/lsa.2015.40

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Bioinspired optical antennas: gold plant viruses

Original Articles

- Bioinspired optical antennas: gold plant viruses
- Light: Science & Applications Vol. 4, Issue 2, (2015)
- Affiliations：
  
  1.Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA
  2.Berkeley Sensor and Actuator Center, University of California at Berkeley, Berkeley, CA 94720, USA
  3.Department of Plant & Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USA
  4.Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA 94720, USA
  5.Biophysics Graduate Program, University of California at Berkeley, Berkeley, CA 94720, USA
- Author bio：
  
  LP Lee, Department of Electrical Engineering and Computer Sciences, University of California at Berkeley, Berkeley, CA 94720, USA. E-mail: lplee@berkeley.edu
- Funds：
- DOI：10.1038/lsa.2015.40
  CLC：
- Published：2015-06，
  
  Published Online：13 January 2015，
  
  Received：05 September 2014，
  
  Revised：30 December 2014，
  
  Accepted：11 January 2015
- Accepted：
Scan QR Code
Hong, S. G. et al. Bioinspired optical antennas: gold plant viruses. Light: Science & Applications, 4, e267 (2015).
DOI：

Hong, S. G. et al. Bioinspired optical antennas: gold plant viruses. Light: Science & Applications, 4, e267 (2015). DOI： 10.1038/lsa.2015.40.

摘要

Abstract

The ability to capture the chemical signatures of biomolecules (i.e.

electron-transfer dynamics) in living cells will provide an entirely new perspective on biology and medicine. This can be accomplished using nanoscale optical antennas that can collect

resonate and focus light from outside the cell and emit molecular spectra. Here

we describe biologically inspired nanoscale optical antennas that utilize the unique topologies of plant viruses (and thus

are called gold plant viruses) for molecular fingerprint detection. Our electromagnetic calculations for these gold viruses indicate that capsid morphologies permit high amplification of optical scattering energy compared to a smooth nanosphere. From experimental measurements of various gold viruses based on four different plant viruses

we observe highly enhanced optical cross-sections and the modulation of the resonance wavelength depending on the viral morphology. Additionally

in label-free molecular imaging

we successfully obtain higher sensitivity (by a factor of up to 10

) than can be achieved using similar-sized nanospheres. By virtue of the inherent functionalities of capsids and the plasmonic characteristics of the gold layer

a gold virus-based antenna will enable cellular targeting

imaging and drug delivery.

关键词

Keywords

molecular sensornanophotonicsoptical antennaoptical spectroscopyplant virusplasmonicsplasmonic resonant energy transfer (PRET)surface enhanced Raman scattering (SERS)

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