
1.Institute of Photonics Technology, Jinan University, Guangzhou 510632, China
2.School of Communication and Information Engineering, University of Electronic Science and Technology, Chengdu 610051, China
3.The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, China
4.Biomedical Engineering Department, University of Michigan, Ann Arbor, Michigan 48109, USA
5.Department of Applied Physics, Hong Kong Polytechnic University, Hong Kong S.A.R., China
ZH Li, Email: li_zhaohui@hotmail.com
XM Zhang, Email: apzhang@polyu.edu.hk
Published:2015-09,
Published Online:12 March 2015,
Received:09 October 2014,
Revised:24 February 2015,
Accepted:12 March 2015
Scan QR Code
Bao, Y. et al. A digitally generated ultrafine optical frequency comb for spectral measurements with 0.01-pm resolution and 0.7-µs response time. Light: Science & Applications, 4, e300 (2015).
Bao, Y. et al. A digitally generated ultrafine optical frequency comb for spectral measurements with 0.01-pm resolution and 0.7-µs response time. Light: Science & Applications, 4, e300 (2015). DOI: 10.1038/lsa.2015.73.
Optical spectral measurements are crucial for optical sensors and many other applications
but the prevailing methods
such as optical spectrum analysis and tunable laser spectroscopy
often have to make compromises among resolution
speed
and accuracy. Optical frequency combs are widely used for metrology of discrete atomic and molecular spectral lines. However
they are usually generated by optical methods and have large comb spacing
which limits the resolution for direct sampling of continuous spectra. To overcome these problems
this paper presents an original method to digitally generate an ultrafine optical frequency comb (UFOFC) as the frequency ruler for spectral measurements. Each comb line provides one sampling point
and the full spectrum can be captured at the same time using coherent detection. For an experimental demonstration
we adopted the inverse fast Fourier transform to generate a UFOFC with a comb spacing of 1.46 MHz over a 10-GHz range and demonstrated its functions using a Mach-Zehnder refractive index sensor. The UFOFC obtains a spectral resolution of 0.01 pm and response time of 0.7 μs; both represent 100-fold improvements over the state of the art and could be further enhanced by several orders of magnitude. The UFOFC presented here could facilitate new label-free sensor applications that require both high resolution and fast speed
such as measuring binding kinetics and single-molecule dynamics.
coherent detectiondigital signal processoptical frequency combsoptical sensorsoptical spectrometry
White IM, Fan X. On the performance quantification of resonant refractive index sensors.Opt Express2008;16: 1020–1028..
Vollmer F, Arnold S. Whispering-gallery-mode biosensing: label-free detection down to single molecules.Nat Methods2008;5: 591–596..
Liang XJ, Liu AQ, Lim CS, Ayi TC, Yap PH. Determining refractive index of single living cell using integrated microchip.Sens Actuators A2007;133: 349–354..
Song WZ, Zhang XM, Liu AQ, Lim CS, Yap PHet al. Refractive index measurement of single living cells using on-chip Fabry-Pérot cavity.Appl Phys Lett2006;89: 203901..
Zhu J, Ozdemir SK, Xiao YF, Li L, He Let al. On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Qmicroresonator.Nat Photon2010;4: 46–49..
Lackner M.Gas Sensing in Industry by Tunable Diode Laser Spectroscopy (TDLS). Vienna, Australia: ProcessEng Engineering GmbH; 2008.
Dyroff C.Tunable Diode-Laser Absorption Spectroscopy for Trace-Gas Measurements with High Sensitivity and Low Drift. Karlsruhe, Germany: KIT Scientific; 2010.
Frish MB, Wainner RT, Laderer MC, Parameswaran KR, Sonnenfroh DM. Precision and Accuracy of Miniature Tunable Diode Laser Absorption Spectrometers. Proc. SPIE 8032, Next-Generation Spectroscopic Technologies Ⅳ, 803209, 2011.
Dale E, Liang W, Eliyahu D, Savchenkov AA, Ilchenko VS, Matsko AB. On Phase Noise of Self-injection Locked Semiconductor Lasers. Proc. SPIE 8960, Laser Resonators, Microresonators, and Beam Control XVI, 89600X, 2014.
Nunoya N, IshiiH, Iga R. High-speed tunable distributed amplification distributed feedback (TDA-DFB) lasers.NTT Tech Rev2012;10: 1–7..
Newbury NR. Searching for applications with a fine-tooth comb.Nat Photon2011;5: 186–188..
Udem T, Holzwarth R, Hänsch TW. Optical frequency metrology.Nature2002;416: 233–237..
Ye J, Cundiff ST (eds. ).Femtosecond Optical Frequency Comb: Principle, Operation, and Applications. Norwell, USA: Springer, 2005.
Bartels A, Heinecke D, Diddams SA. 10-GHz self-referenced optical frequency comb.Science2009;326: 681..
Kippenberg TJ, Holzwarth R, Diddams SA. Microresonator-based optical frequency combs.Science2011;332: 555–559..
Marian A, Stowe MC, Lawall JR, Felinto D, Ye J. United time-frequency spectroscopy for dynamics and global structure.Science2004;306: 2063–2068..
Thorpe MJ, Ye J. Cavity-enhanced direct frequency comb spectroscopy.Appl Phys B2008;91: 397–414..
Adler F, Thorpe MJ, Cossel KC, Ye J. Cavity-enhanced direct frequency comb spectroscopy: technology and applications.Ann Rev Anal Chem2010;3: 175–205..
Fleisher AJ, Bjork BJ, Bui TQ, Cossel KC, Okumura M. Mid-infrared time-resolved frequency comb spectroscopy of transient free radicals.J Phys Chem Lett2014;5: 2241–2246..
Foltynowicz A, Ban T, Masłowski P, Adler F, Ye J. Quantum-noise-limited optical frequency comb spectroscopy.Phys Rev Lett2011;107: 233002..
Diddams SA, Hollberg L, Mbele V. Molecular fingerprinting with the resolved modes of a femtosecond laser frequency comb.Nature2007;445: 627–630..
Mandon J, Guelachvili G, Picqué N. Fourier transform spectroscopy with a laser frequency comb.Nat Photon2009;3: 99–102..
Ideguchi T, Holzner S, Bernhardt B, Guelachvili G, Picqué Net al. Coherent Raman spectro-imaging with laser frequency combs.Nature2013;502: 355–358..
Ideguchi T, Poisson A, Guelachvili G, Picqué N, Hänsch TW. Adaptive real-time dual-comb spectroscopy.Nat Comm2014;5: 3375..
Li J, Li Z. Frequency-locked multicarrier generator based on a complementary frequency shifter with double recirculating frequency-shifting loops.Opt Lett2013;38: 359–361..
Yi X, Li Z, Bao Y, Qiu K. Characterization of passive optical components by DSP-based optical channel estimation.IEEE Photon Technol Lett2012;24: 443–445..
Jin C, Bao Y, Li Z, Gui T, Shang Het al. High-resolution optical spectrum characterization using optical channel estimation and spectrum stitching technique.Opt Lett2013;38: 2314–2316..
Betzler K, Gröne A, Schmidt N, Voigt P. Interferometric measurement of refractive indices.Rev Sci Instrum1988;59: 652–653..
Tian Z, Yam SS, Barnes J, Bock W, Greig Pet al. Refractive index sensing with Mach–Zehnder interferometer based on concatenating two single-mode fiber tapers.IEEE Photon Technol Lett2008;20: 626–628..
Schubert T, Haase N, Kück H, Gottfried-Gottfried R. Refractive-index measurements using an integrated Mach-Zehnder interferorneter.Sens Actuators A1997;60: 108–112..
Qi ZM, Matsuda N, Itoh K, Murabayashi M, Lavers CR. A design for improving the sensitivity of a Mach-Zehnder interferometer to chemical and biological measurands.Sens Actuators B2002;81: 254–258..
Wang Y, Yang M, Wang DN, Liu S, Lu P. Fiber in-line Mach–Zehnder interferometer fabricated by femtosecond laser micromachining for refractive index measurement with high sensitivity.J Opt Soc Am B2010;27: 370–374..
Liu Q, Tu X, Kim KW, Kee JS, Shin Yet al. Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide.Sens Actuators B2013;188: 681–688..
Kamikawachi RC, Abe I, Paterno AS, Kalinowski HJ, Muller Met al. Determination of thermo-optic coefficient in liquids with fiber Bragg grating refractometer.Opt Commun2008;281: 621–625..
Kim YH, Park SJ, Jeon SW, Ju S, Park CSet al. Thermo-optic coefficient measurement of liquids based on simultaneous temperature and refractive index sensing capability of a two-modefiber interferometric probe.Opt Express2012;20: 23744–23754..
Ghosh G.Handbook of Thermo-optic Coefficients of Optical Materials with Applications. San Diego, USA: Academic Press, 1998.
Ye J. Optical metrology: everything under control.Nat Photon2007;1: 447–448..
Lin VS, Motesharei K, Dancil KP, Sailor MJ, Ghadiri MR. A porous silicon-based optical interferometric biosensor.Science1997;278: 840–843..
Hou BH, Takanaga H, Grossmann G, Chen LQ, Qu XQet al. Optical sensors for monitoring dynamic changes of intracellular metabolite levelsin mammalian cells.Nat Protoc2011;6: 1818–1833..
Oh KJ, Cash KJ, Plaxco KW. Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides.Chem2009;15: 2244–2251..
Fang Y. Label-free cell-based assays with optical biosensors in drug discovery.Assay Drug Dev Technol2006;4: 583–595..
0
Views
0
Downloads
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution
京公网安备11010802024621