A flexible and superhydrophobic upconversion-luminescence membrane as an ultrasensitive fluorescence sensor for single droplet detection

Kui-Chao Liu; Zhen-Yi Zhang; Chong-Xin Shan; Zhi-Qing Feng; Jia-Su Li; Chun-Lei Song; Ya-Nan Bao; Xiao-Hui Qi; Bin Dong

doi:10.1038/lsa.2016.136

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A flexible and superhydrophobic upconversion-luminescence membrane as an ultrasensitive fluorescence sensor for single droplet detection

Original Articles

- A flexible and superhydrophobic upconversion-luminescence membrane as an ultrasensitive fluorescence sensor for single droplet detection
- Light: Science & Applications Vol. 5, Issue 3, (2016)
- Affiliations：
  
  1.Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission, Dalian Nationalities University, 18 Liaohe West Road, Dalian 116600, China
  2.State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China
  3.School of Physics and Engineering, Zhengzhou University, Zhengzhou 450001, China
- Author bio：
  
  ZY Zhang, Email: zhangzy@dlnu.edu.cn
  B Dong, Email: dong@dlnu.edu.cn
- Funds：
- DOI：10.1038/lsa.2016.136
  CLC：
- Published：2016-09，
  
  Published Online：21 March 2016，
  
  Received：02 November 2015，
  
  Revised：06 March 2016，
  
  Accepted：10 March 2016
- Accepted：
Scan QR Code
Liu, K. C. et al. A flexible and superhydrophobic upconversion-luminescence membrane as an ultrasensitive fluorescence sensor for single droplet detection. Light: Science & Applications, 5, e16136 (2016).
DOI：

Liu, K. C. et al. A flexible and superhydrophobic upconversion-luminescence membrane as an ultrasensitive fluorescence sensor for single droplet detection. Light: Science & Applications, 5, e16136 (2016). DOI： 10.1038/lsa.2016.136.

摘要

Abstract

A Ln

-doped (Yb

or Yb

co-doped) NaYF

nanoparticle/polystyrene hybrid fibrous membrane (HFM) was fabricated using an electrospinning technique. The HFM shows upconversion luminescence (UCL)

flexibility

superhydrophobicity and processability. The UCL membrane can be used as a fluorescence sensor to detect bioinformation from a single water droplet (~10 μl). Based on the fluorescence resonance energy transfer

the detection limits of this sensor can reach 1 and 10 ppb for the biomolecule

avidin

and the dye molecule

Rhodamine B

respectively

which are superior to most of the fluorescence sensors reported in previous works. After the f

luorescence detection

the target droplet was easily removed without residues on the UCL membrane surface due to its superhydrophobic property

which exhibits an excellent recyclability that cannot be achieved by traditional liquid-based detection systems.

关键词

Keywords

electrospinningfibrous membranefluorescence resonance energy transferfluorescence sensorsuperhydrophobic surfaceupconversion luminescence

references

Avouris P, Freitag M, Perebeinos V. Carbon-nanotube photonics and optoelectronics.Nat Photonics2008;2: 341–350..

Zhou PW, Zhou DL, Tao L, Zhu YS, Xu Wet al. 320-fold luminescence enhancement of [Ru(dpp)3]Cl2 dispersed on PMMA opal photonic crystals and highly improved oxygen sensing performance.Light Sci Appl2014;3: e209, doi:10.1038/lsa.2014.90..

Huang XY, Han SY, Huang W, Liu XG. Enhancing solar cell efficiency: the search for luminescent materials as spectral converters.Chem Soc Rev2013;42: 173–201..

Gai SL, Li CX, Yang PP, Lin J. Recent progress in rare earth micro/nanocrystals: soft chemical synthesis, luminescent properties, and biomedical applications.Chem Rev2014;114: 2343–2389..

Huang P, Zheng W, Zhou SY, Tu DT, Chen Zet al. Lanthanide-doped LiLuF4 upconversion nanoprobes for the detection of disease biomarkers.Angew Chem Int Ed Engl2014;53: 1252–1257..

Hou ZY, Li CX, Ma PA, Li GG, Cheng ZYet al. Electrospinning preparation and drug-delivery properties of an up-conversion luminescent porous NaYF4: Yb3+, Er3+@silica fiber nanocomposite.Adv Funct Mater2011;21: 2356–2365..

Liu T, Bai X, Miao C, Dai QL, Xu Wet al. Yb2O3/Au upconversion nanocomposites with broad-band excitation for solar cells.J Phys Chem C2014;118: 3258–3265..

Zhang X, Yang PP, Dai YL, Ma PA, Li XJet al. Multifunctional up-converting nanocomposites with smart polymer brushes gated mesopores for cell imaging and thermo/pH dual-responsive drug controlled release.Adv Funct Mater2013;23: 4067–4078..

Ma PA, Xiao HH, Li XX, Li CX, Dai YLet al. Rational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (Ⅳ) delivery and biomedical imaging.Adv Mater2013;25: 4898–4905..

Tang YN, Di WH, Zhai XS, Yang RY, Qin WP. NIR-responsive photocatalytic activity and mechanism of NaYF4: Yb, Tm@TiO2core-shell nanoparticles.ACS Catal2013;3: 405–412..

Xu S, Xu SH, Zhu YS, Xu W, Zhou PWet al. A novel upconversion, fluorescence resonance energy transfer biosensor (FRET) for sensitive detection of lead ions in human serum.Nanoscale2014;6: 12573–12579..

Chen BT, Dong B, Wang J, Zhang S, Xu Let al. Amphiphilic silane modified NaYF4: Yb, Er loaded with Eu(TTA)3(TPPO)2nanoparticles and their multi-functions: dual mode temperature sensing and cell imaging.Nanoscale2013;5: 8541–8549..

Li ZQ, Zhang Y, Jiang S. Multicolor core/shell-structured upconversion fluorescent nanoparticles.Adv Mater2008;20: 4765–4769..

Vetrone F, Naccache R, de la Fuente AJ, Sanz-Rodríguez F, Blazquez-Castro Aet al. Intracellular imaging of HeLa cells by non-functionalized NaYF4: Er3+, Yb3+upconverting nanoparticles.Nanoscale2010;2: 495–498..

Liu Q, Sun Y, Yang TS, Feng W, Li CGet al. Sub-10 nm hexagonal lanthanide-doped NaLuF4 upconversion nanocrystals for sensitive bioimagingin vivo.J Am Chem Soc2011;133: 17122–17125..

Feng W, Sun LD, Yan CH. Ag nanowires enhanced upconversion emission of NaYF4: Yb, Er nanocrystals via a direct assembly method.Chem Commun2009;29: 4393–4395..

Wang F, Liu XG. Upconversion multicolor fine-tuning: visible to near-infrared emission from lanthanide-doped NaYF4nanoparticles.J Am Chem Soc2008;130: 5642–5643..

Liu XM, Zhao JW, Sun YJ, Song K, Yu Yet al. Ionothermal synthesis of hexagonal-phase NaYF4: Yb3+, Er3+/Tm3+upconversion nanophosphors.Chem Commun2009;43: 6628–6630..

Burns JH. Crystal structure of hexagonal sodium neodymium fluoride and related compounds.Inorg Chem1965;4: 881–886..

Zhang JH, Hao ZD, Li J, Zhang X, Luo YSet al. Observation of efficient population of the red-emitting state from the green state by non-multiphonon relaxation in the Er3+–Yb3+system.Light Sci Appl2015;4: e239, doi:10.1038/lsa.2015.12..

Qin WP, Liu ZY, Sin CN, Wu CF, Qin GSet al. Multi-ion cooperative processes in Yb3+clusters.Light Sci Appl2014;3: e193, doi:10.1038/lsa.2014.74..

Bakalova R, Ohba H, Zhelev Z, Ishikawa M, Baba Y. Quantum dots as photosensitizers?Nat Biotechnol2004;22: 1360–1361..

Liu JL, Liu Y, Liu Q, Li CY, Sun LNet al. Iridium(Ⅲ) complex-coated nanosystem for ratiometric upconversion luminescence bioimaging of cyanide anions.J Am Chem Soc2011;133: 15276–15279..

Chen R, Shen YQ, Xiao F, Liu B, Gurzadyan GGet al. Surface Eu-treated ZnO nanowires with efficient red emission.J Phys Chem C2010;114: 18081–18084..

Tu DT, Liu LQ, Ju Q, Liu YS, Zhu HMet al. Time-resolved FRET biosensor based on amine-functionalized lanthanide-doped NaYF4nanocrystals.Angew Chem Int Ed Engl2011;50: 6306–6310..

Kuningas K, Rantanen T, Ukonaho T, Lövgren T, Soukka T. Homogeneous assay technology based on upconverting phosphors.Anal Chem2005;77: 7348–7355..

Xiao F, Chen R, Shen YQ, Dong ZL, Wang HHet al. Efficient energy transfer and enhanced infrared emission in Er-doped ZnO-SiO2composites.J Phys Chem C2012;116: 13458–13462..

Chen R, Ta VD, Xiao F, Zhang QY, Sun HD. Multicolor hybrid upconversion nanoparticles and their improved performance as luminescence temperature sensors due to energy transfer.Small2013;9: 1052–1057..

Xu S, Xu W, Wang YF, Zhang S, Zhu YSet al. NaYF4: Yb, Tm nanocrystals and TiO2inverse opal composite films: a novel device for upconversion enhancement and solid-based sensing of avidin.Nanoscale2014;6: 5859–5870..

Zhang ZY, Shao CL, Gao F, Li XH, Liu YC. Enhanced ultraviolet emission from highly dispersed ZnO quantum dots embedded in poly(vinyl pyrrolidone) electrospun nanofibers.J Colloid Interface Sci2010;347: 215–220..

Dong B, Song HW, Yu HQ, Zhang H, Qin RFet al. Upconversion properties of Ln3+doped NaYF4/polymer composite fibers prepared by electrospinning.J Phys Chem C2008;112: 1435–1440..

Zou P, Hong X, Ding YD, Zhang ZY, Chu XYet al. Up-conversion luminescence of NaYF4: Yb3+/Er3+nanoparticles embedded into PVP nanotubes with controllable diameters.J Phys Chem C2012;116: 5787–5791..

Sui XM, Shao CL, Liu YC. White-light emission of polyvinyl alcohol/ZnO hybrid nanofibers prepared by electrospinning.Appl Phys Lett2005;87: 113115..

Fridrikh SV, Yu JH, Brenner MP, Rutledge GC. Controlling the fiber diameter during electrospinning.Phys Rev Lett2003;90: 144502..

He D, Hu B, Yao QF, Wang K, Yu SH. Large-scale synthesis of flexible free-standing SERS substrates with high sensitivity: electrospun PVA nanofibers embedded with controlled alignment of silver nanoparticles.ACS Nano2009;3: 3993–4002..

Zhang CL, Lv KP, Cong HP, Yu SH. Controlled assemblies of gold nanorods in PVA nanofiber matrix as flexible free-standing SERS substrates by electrospinning.Small2012;8: 648–653..

Zhang CL, Lv KP, Hu NY, Yu L, Ren XFet al. Macroscopic-scale alignment of ultralong Ag nanowires in polymer nanofiber mat and their hierarchicalstructures by magnetic-field-assisted electrospinning.Small2012;8: 2936–2940..

Zhang CL, Lv KP, Huang HT, Cong HP, Yu SH. Co-assembly of Au nanorods with Ag nanowires within polymer nanofiber matrix for enhanced SERS property by electrospinning.Nanoscale2012;4: 5348–5355..

Jiang L, Zhao Y, Zhai J. A lotus-leaf-like superhydrophobic surface: a porous microsphere/nanofiber composite film prepared by electrohydrodynamics.Angew Chem Int Ed Engl2004;43: 4338–4341..

Patankar NA. On the modeling of hydrophobic contact angles on rough surfaces.Langmuir2003;19: 1249–1253..

Wang LL, Zhang XT, Fu Y, Li B, Liu YC. Bioinspired preparation of ultrathin SiO2shell on ZnO nanowire array for ultraviolet-durable superhydrophobicity.Langmuir2009;25: 13619–13624..

Muthiah P, Hsu SH, Sigmund W. Coaxially electrospun PVDF-teflon AF and teflon AF-PVDF core-sheath nanofiber mats with superhydrophobic properties.Langmuir2010;26: 12483–12487..

ThomasIII SW, Joly GD, Swager TM. Chemical sensors based on amplifying fluorescent conjugated polymers.Chem Rev2007;107: 1339–1386..

Feng FD, He F, An LL, Wang S, Li YLet al. Fluorescent conjugated polyelectrolytes for biomacromolecule detection.Adv Mater2008;20: 2959–2964..

Wang S, Bazan GC. Optically amplified RNA-protein detection methods using light-harvesting conjugated polymers.Adv Mater2003;15: 1425–1428..

Tang F, He F, Cheng HC, Li LD. Self-assembly of conjugated polymer-Ag@SiO2hybrid fluorescent nanoparticles for application to cellular imaging.Langmuir2010;26: 11774–11778..

He TC, Chen R, Lin WW, Huang F, Sun HD. Two-photon-pumped stimulated emission from ZnO single crystal.Appl Phys Lett2011;99: 081902..

Adachi K, Watanabe K, Yamazaki S. pH-responsive switchable aggregation phenomena of xanthene dyes adsorbedon tungsten(Ⅵ) oxide colloid surface.Ind Eng Chem Res2014;53: 13046–13057..

Dey D, Bhattacharjee D, Chakraborty S, Hussain SA. Effect of nanoclay laponite and pH on the energy transfer between fluorescent dyes.J Photoch Photobio A2013;252: 174–182..

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