Manipulation and detection of single nanoparticles and biomolecules by a photonic nanojet

Yu-Chao Li; Hong-Bao Xin; Hong-Xiang Lei; Lin-Lin Liu; Yan-Ze Li; Yao Zhang; Bao-Jun Li

doi:10.1038/lsa.2016.176

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Manipulation and detection of single nanoparticles and biomolecules by a photonic nanojet

Original Articles

- Manipulation and detection of single nanoparticles and biomolecules by a photonic nanojet
- Light: Science & Applications Vol. 5, Issue 4, (2016)
- Affiliations：
  
  1.Institute of Nanophotonics, Jinan University, Guangzhou 511443, China
  2.State Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China
  3.State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, Jinan 250100, China
  4.National Engineering Research Centre for Beijing Biochip Technology, Beijing 102206, China
- Author bio：
  
  Y Zhang, Email: zhyao5@jnu.edu.cn
  BJ Li, Email: baojunli@jnu.edu.cn
- Funds：
- DOI：10.1038/lsa.2016.176
  CLC：
- Published：2016-12，
  
  Published Online：07 June 2016，
  
  Received：30 December 2015，
  
  Revised：30 May 2016，
  
  Accepted：03 June 2016
- Accepted：
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Li, Y. C. et al. Manipulation and detection of single nanoparticles and biomolecules by a photonic nanojet. Light: Science & Applications, 5, e16176 (2016).
DOI：

Li, Y. C. et al. Manipulation and detection of single nanoparticles and biomolecules by a photonic nanojet. Light: Science & Applications, 5, e16176 (2016). DOI： 10.1038/lsa.2016.176.

摘要

Abstract

Optical methods to manipulate and detect nanoscale objects are highly desired in both nanomaterials and molecular biology fields. Optical tweezers have been used to manipulate objects that range in size from a few hundred nanometres to several micrometres. The emergence of near-field methods that overcome the diffraction limit has enabled the manipulation of objects below 100 nm. A highly free manipulation with signal-enhanced real-time detection

however

remains a challenge for single sub-100-nm nanoparticles or biomolecules. Here we show an approach that uses a photonic nanojet to perform the manipulation and detection of single sub-100-nm objects. With the photonic nanojet generated by a dielectric microlens bound to an optical fibre probe

three-dimensional manipulations were achieved for a single 85-nm fluorescent polystyrene nanoparticle as well as for a plasmid DNA molecule. Backscattering and fluorescent signals were detected with the enhancement factors up to ~10

and ~30

respectively.

The demonstrated approach provides a potentially powerful tool for nanostructure assembly

biosensing and single-biomolecule studies.

关键词

Keywords

nanoparticlesoptical detectionoptical manipulationsingle biomolecules

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