Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice

X Luís Deán-Ben; Thomas F Fehm; Steven J Ford; Sven Gottschalk; Daniel Razansky

doi:10.1038/lsa.2016.247

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Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice

Original Articles

- Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice
- Light: Science & Applications Vol. 6, Issue 2, (2017)
- Affiliations：
  
  1.Institute for Biological and Medical Imaging (IBMI), Helmholtz Center Munich, 85764 Neuherberg, Germany
  2.School of Medicine and School of Bioengineering, Technical University of Munich, 81675 Munich, Germany
- Author bio：
  
  XL Dean-Ben, Email: xl.deanben@helmholtz-muenchen.de
- Funds：
- DOI：10.1038/lsa.2016.247
  CLC：
- Published：2017-06，
  
  Published Online：01 November 2016，
  
  Received：26 April 2016，
  
  Revised：20 October 2016，
  
  Accepted：28 October 2016
- Accepted：
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Deán-Ben, X. L. et al. Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice. Light: Science & Applications, 6, e16247 (2017).
DOI：

Deán-Ben, X. L. et al. Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice. Light: Science & Applications, 6, e16247 (2017). DOI： 10.1038/lsa.2016.247.

摘要

Abstract

Imaging dynamics at different temporal and spatial scales is essential for understanding the biological complexity of living organisms

disease state and progression. Optoacoustic imaging has been shown to offer exclusive applicability across multiple scales with excellent optical contrast and high resolution in deep-tissue observations. Yet

efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition time and effective field of view. Herein

we introduce the spiral volumetric optoacoustic tomography technique that provides spectrally enriched high-resolution contrast across multiple spatiotemporal scales.

In vivo

experiments in mice demonstrate a wide range of dynamic imaging capabilities

from three-dimensional high-frame-rate visualization of moving organs and contrast agent kinetics in selected areas to whole-body longitudinal studies with unprecedented image quality. The newly introduced paradigm shift in imaging of multi-scale dynamics adds to the multifarious advantages provided by the optoacoustic technology for structural

functional and molecular imaging.

关键词

Keywords

multi-scale dynamicsmulti-spectral imagingoptoacoustic tomographyreal-time imagingwhole-body imaging

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