Non-interferometric photoacoustic remote sensing microscopy

Parsin Hajireza; Wei Shi; Kevan Bell; Robert J Paproski; Roger J Zemp

doi:10.1038/lsa.2016.278

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Non-interferometric photoacoustic remote sensing microscopy

Original Articles

- Non-interferometric photoacoustic remote sensing microscopy
- Light: Science & Applications Vol. 6, Issue 2, (2017)
- Affiliations：
  
  1.Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, T6G 2V4 Canada
  2.IllumiSonics, Inc., 5205-38A Ave. N.W., Edmonton, Alberta, T6L 2J4, Canada
- Author bio：
  
  P Hajireza, Email: parsin@illumisonics.com
  RJ Zemp, Email: rzemp@ualberta.ca
- Funds：
- DOI：10.1038/lsa.2016.278
  CLC：
- Published：2017-06，
  
  Published Online：09 January 2017，
  
  Received：23 June 2016，
  
  Revised：21 December 2016，
  
  Accepted：04 January 2017
- Accepted：
Scan QR Code
Hajireza, P. et al. Non-interferometric photoacoustic remote sensing microscopy. Light: Science & Applications, 6, e16278 (2017).
DOI：

Hajireza, P. et al. Non-interferometric photoacoustic remote sensing microscopy. Light: Science & Applications, 6, e16278 (2017). DOI： 10.1038/lsa.2016.278.

摘要

Abstract

Elasto-optical refractive index modulation due to photoacoustic initial pressure transients produced significant reflection of a probe beam when the absorbing interface had an appreciable refractive index difference. This effect was harnessed in a new form of non-contact optical resolution photoacoustic microscopy called photoacoustic remote sensing microscopy. A non-interferometric system architecture with a low-coherence probe beam precludes detection of surface oscillations and other phase-modulation phenomenon. The probe beam was confocal with a scanned excitation beam to ensure detection of initial pressure-induced intensity reflections at the subsurface origin where pressures are largest. Phantom studies confirmed signal dependence on optical absorption

index contrast and excitation fluence.

In vivo

imaging of superficial microvasculature and melanoma tumors was demonstrated with ~2.7±0.5 μm lateral resolution.

关键词

Keywords

all opticalmedical imagingoptical resolutionphotoacousticremote sensing

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