Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules

Hyukjin Jung; Moonseong Park; Minhee Kang; Ki-Hun Jeong

doi:10.1038/lsa.2016.9

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Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules

Original Articles

- Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules
- Light: Science & Applications Vol. 5, Issue 1, (2016)
- Affiliations：
  
  Department of Bio and Brain Engineering, KAIST Institute for Optical Science and Technology, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Korea
- Author bio：
  
  KH Jeong, Email: kjeong@kaist.ac.kr
- Funds：
- DOI：10.1038/lsa.2016.9
  CLC：
- Published：2016-03，
  
  Published Online：23 August 2015，
  
  Received：08 March 2015，
  
  Revised：11 August 2015，
  
  Accepted：17 August 2015
- Accepted：
Scan QR Code
Jung, H. et al. Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules. Light: Science & Applications, 5, e16009 (2016).
DOI：

Jung, H. et al. Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules. Light: Science & Applications, 5, e16009 (2016). DOI： 10.1038/lsa.2016.9.

摘要

Abstract

High-throughput small-molecule assays play essential roles in biomedical diagnosis

drug discovery

environmental analysis

and physiological function research. Nanoplasmonics holds a great potential for the label-free detection of small molecules at extremely low concentrations. Here

we report the development of nanoplasmonic paper (NP-paper) for the rapid separation and ultrasensitive detection of mixed small molecules. NP-paper employs nanogap-rich silver nanoislands on cellulose fibers

which were simply fabricated at the wafer level by using low-temperature solid-state dewetting of a thin silver film. The nanoplasmonic detection allows for the scalable quantification and identification of small molecules over broad concentration ranges. Moreover

the combination of chromatographic separation and nanoplasmonic detection allows both the highly sensitive fluorescence detection of mixed small molecules at the attogram level and the label-free detection at the sub-nanogram level based on surface-enhanced Raman scattering. This novel material provides a new diagnostic platform for the high-throughput

low-cost

and label-free screening of mixed small molecules as an alternative to conventional paper chromatography.

关键词

Keywords

nanoplasmonicspaper chromatographyplasmon-enhanced spectroscopysilver nanoislandssmall-molecule assay

references

Gottesfeld JM, Neely L, Trauger JW, Baird EE, Dervan PB. Regulation of gene expression by small molecules.Nature1997;387: 202–205..

Stockwell BR. Exploring biology with small organic molecules.Nature2004;432: 846–854..

Schreiber SL. Small molecules: the missing link in the central dogma.Nat Chem Biol2005;1: 64–66..

Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging.Proc Natl Acad Sci USA1993;90: 7915–7922..

Jackson TM, Ekins RP. Theoretical limitations on immunoassay sensitivity: current practice and potential advantages of fluorescent Eu3+chelates as non-radioisotopic tracers.J Immunol Methods1986;87: 13–20..

Kaddurah-Daouk R, Kristal BS, Weinshilboum RM. Metabolomics: a global biochemical approach to drug response and disease.Annu Rev Pharmacol Toxicol2008;48: 653–683..

Espada A, Molina-Martin M. Capillary electrophoresis and small molecule drug discovery: a perfect match?Drug Discov Today2012;17: 396–404..

Dentinger BTM, Margaritescu S, Moncalvo J-M. Rapid and reliable high-throughput methods of DNA extraction for use in barcoding and molecular systematics of mushrooms.Mol Ecol Resour2010;10: 628–633..

Consden R, Gordon AH, Martin AJ. Qualitative analysis of proteins: a partition chromatographic method using paper.Biochem J1944;38: 224–232..

Fletcher J. Filter-paper dot-immunobinding assay for detection of spiroplasma-citri.Appl Environ Microbiol1987;53: 183–184..

Heberling RL, Kalter SS. Rapid dot-immunobinding assay on nitrocellulose for viral antibodies.J Clin Microbiol1986;23: 109–113..

Martinez AW, Phillips ST, Butte MJ, Whitesides GM. Patterned paper as a platform for inexpensive, low-volume, portable bioassays.Angew Chem Int Ed2007;46: 1318–1320..

Hossain SMZ, Luckham RE, Smith AM, Lebert JM, Davies LMet al. Development of a bioactive paper sensor for detection of neurotoxins using piezoelectric inkjet printing of sol−gel-derived bioinks.Anal Chem2009;81: 5474–5483..

Ali MM, Aguirre SD, Xu Y, Filipe CDM, Pelton Ret al. Detection of DNA using bioactive paper strips.Chem Commun2009; 6640–6642..

Chen H, Kou X, Yang Z, Ni W, Wang J. Shape- and size-dependent refractive index sensitivity of gold nanoparticles.Langmuir2008;24: 5233–5237..

Lei DY, Li J, Fernández-Domínguez AI, Ong HC, Maier SA. Geometry dependence of surface plasmon polariton lifetimes in nanohole arrays.ACS Nano2009;4: 432–438..

Jensen TR, Duval ML, Kelly KL, Lazarides AA, Schatz GCet al. Nanosphere lithography: effect of the external dielectric medium on the surface plasmon resonance spectrum of a periodic array of silver nanoparticles.J Phys Chem B1999;103: 9846–9853..

Zhang J, Fu Y, Liang D, Nowaczyk K, Zhao RYet al. Single-cell fluorescence imaging using metal plasmon-coupled probe 2: single-molecule counting on lifetime image.Nano Lett2008;8: 1179–1186..

Park S-G, Ahn M-S, Oh Y-J, Kang M, Jeong Yet al. Nanoplasmonic biopatch forin vivosurface enhanced Raman spectroscopy.Biochip J2014;8: 289–294..

Duhr S, Braun D. Why molecules move along a temperature gradient.Proc Natl Acad Sci USA2006;103: 19678–19682..

Kang T, Hong S, Choi Y, Lee LP. The effect of thermal gradients in SERS spectroscopy.Small2010;6: 2649–2652..

Kasera S, Biedermann F, Baumberg JJ, Scherman OA, Mahajan S. Quantitative SERS using the sequestration of small molecules inside precise plasmonic nanoconstructs.Nano Lett2012;12: 5924–5928..

Oh Y-J, Park S-G, Kang M-H, Choi J-H, Nam Yet al. Beyond the SERS: Raman enhancement of small molecules using nanofluidic channels with localized surface plasmon resonance.Small2011;7: 184–188..

Park M, Oh Y-J, Park S-G, Yang S-B, Jeong K-H. Electrokinetic preconcentration of small molecules within volumetric electromagnetic hotspots in surface enhanced Raman scattering.Small2015;11: 2487–2492..

Lee CH, Hankus ME, Tian L, Pellegrino PM, Singamaneni S. Highly sensitive surface enhanced Raman scattering substrates based on filter paper loaded with plasmonic nanostructures.Anal Chem2011;83: 8953–8958..

Yu WW, White IM. Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates.Analyst2013;138: 3679–3686..

Tseng S-C, Yu C-C, Wan D, Chen H-L, Wang LAet al. Eco-friendly plasmonic sensors: using the photothermal effect to prepare metal nanoparticle-containing test papers for highly sensitive colorimetric detection.Anal Chem2012;84: 5140–5145..

Polavarapu L, Porta AL, Novikov SM, Coronado-Puchau M, Liz-Marzán LM. Pen-on-paper approach toward the design of universal surface enhanced Raman scattering substrates.Small2014;10: 3065–3071..

Campbell CT. Ultrathin metal films and particles on oxide surfaces: structural, electronic and chemisorptive properties.Surf Sci Rep1997;27: 1–111..

Le Ru EC, Blackie E, Meyer M, Etchegoin PG. Surface enhanced Raman scattering enhancement factors: a comprehensive study.J Phys Chem C2007;111: 13794–13803..

Kang M, Kim J-J, Oh Y-J, Park S-G, Jeong K-H. A deformable nanoplasmonic membrane reveals universal correlations between plasmon resonance and surface enhanced Raman scattering.Adv Mater2014;26: 4510–4514..

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