Through-needle all-optical ultrasound imaging <italic style="font-style: italic">in vivo</italic>: a preclinical swine study

Malcolm C Finlay; Charles A Mosse; Richard J Colchester; Sacha Noimark; Edward Z Zhang; Sebastien Ourselin; Paul C Beard; Richard J Schilling; Ivan P Parkin; Ioannis Papakonstantinou; Adrien E Desjardins

doi:10.1038/lsa.2017.103

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Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study

Original Articles

- Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study
- Light: Science & Applications Vol. 6, Issue 4, (2017)
- Affiliations：
  
  1.William Harvey Cardiovascular Research Institute, Queen Mary University of London and Barts Heart Centre, London EC1A 7BE, UK
  2.Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, Charles Bell House, 67-73 Riding House Street, London W1W 7EJ, UK
  3.UCL Centre for Materials Research, Department of Chemistry, University College London, London WC1H 0AJ, UK
  4.Department of Electronic and Electrical Engineering, University College London, London WC1E 7JE, UK
- Author bio：
  
  AE Desjardins, Email: a.desjardins@ucl.ac.uk
- Funds：
- DOI：10.1038/lsa.2017.103
  CLC：
- Published：2017-12，
  
  Published Online：01 December 2017，
  
  Received：04 January 2017，
  
  Revised：11 June 2017，
  
  Accepted：14 June 2017
- Accepted：
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Finlay, M. C. et al. Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study. Light: Science & Applications, 6, e17103 (2017).
DOI：

Finlay, M. C. et al. Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study. Light: Science & Applications, 6, e17103 (2017). DOI： 10.1038/lsa.2017.103.

摘要

Abstract

High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures. Here

we demonstrate that an all-optical ultrasound transducer

through which light guided by optical fibers is used to generate and receive ultrasound

is suitable for real-time invasive medical imaging

in vivo

. Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser. The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception. This transducer was integrated within a custom inner transseptal needle (diameter 1.08 mm; length 78 cm) that included a metallic septum to acoustically isolate the two optical fibers. The use of this needle within the beating heart of a pig provided unprecedented real-time views (50 Hz scan rate) of cardiac tissue (depth: 2.5 cm; axial resolution: 64 μm) and revealed the critical anatomical structures required to safely perform a transseptal crossing: the right and left atrial walls

the right atrial appendage

and the limbus fossae ovalis. This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts.

关键词

Keywords

cardiacmedical devicesoptoacousticphotoacousticultrasound

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Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study

DOI：10.1038/lsa.2017.103

摘要

Abstract

关键词

Keywords

references