Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

Filiz Yesilkoy; Roland A Terborg; Josselin Pello; Alexander A Belushkin; Yasaman Jahani; Valerio Pruneri; Hatice Altug

doi:10.1038/lsa.2017.152

Go to Nature Website

Your Location：

Home >

Browse articles >

Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

Original Articles

- Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager
- Light: Science & Applications Vol. 7, Issue 2, (2018)
- Affiliations：
  
  1.Institute of BioEngineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
  2.ICFO—Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain
  3.ICREA—Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain
- Author bio：
  
  V Pruneri, E-mail: valerio.pruneri@icfo.eu
  H Altug, E-mail: hatice.altug@epfl.ch
- Funds：
- DOI：10.1038/lsa.2017.152
  CLC：
- Published：2018，
  
  Published Online：23 February 2018，
  
  Received：22 August 2017，
  
  Revised：26 October 2017，
  
  Accepted：27 October 2017
- Accepted：
Scan QR Code
Yesilkoy, F. et al. Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager. Light: Science & Applications, 7, 17152 (2018).
DOI：

Yesilkoy, F. et al. Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager. Light: Science & Applications, 7, 17152 (2018). DOI： 10.1038/lsa.2017.152.

摘要

Abstract

Nanophotonics

and more specifically plasmonics

provides a rich toolbox for biomolecular sensing

since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels. So far

biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity changes. However

the phase response of the plasmonic resonances have rarely been exploited

mainly because this requires a more sophisticated optical arrangement. Here we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by plasmonics. It employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical path configuration. This unique combination allows the detection of atomically thin (angstrom-level) topographical features over large areas

enabling simultaneous reading of thousands of microarray elements. As the plasmonic chips are fabricated using scalable techniques and the imaging reader is built with low-cost off-the-shelf consumer electronic and optical components

the proposed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample volumes. Our research opens new horizons for on-site disease diagnostics and remote health monitoring.

关键词

Keywords

interferometric imaginglabel-free plasmonic biosensorslens-free imagingphase interrogationpoint-of-care devicesprotein microarray detection

references

Lopez GA, Estevez M-C, Soler M, Lechuga LM. Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration.Nanophotonics2016;6: 123–136..

Anker JN, Hall WP, Lyandres O, Shah NC, Zhao Jet al. Biosensing with plasmonic nanosensors.Nat Mater2008;7: 442–453..

Sreekanth KV, Alapan Y, ElKabbash M, Ilker E, Hinczewski Met al. Extreme sensitivity biosensing platform based on hyperbolic metamaterials.Nat Mater2016;15: 621–627..

Di Fabrizio E, Schlücker S, Wenger J, Regmi R, Rigneault Het al. Roadmap on biosensing and photonics with advanced nano-optical methods.J Opt2016;18: 063003..

Brolo AG. Plasmonics for future biosensors.Nat Photon2012;6: 709–713..

Lindquist NC, Nagpal P, McPeak KM, Norris DJ, Oh S-H. Engineering metallic nanostructures for plasmonics and nanophotonics.Rep Prog Phys2012;75: 036501..

Pallaoro A, Hoonejani MR, Braun GB, Meinhart CD, Moskovits M. Rapid identification by surface-enhanced raman spectroscopy of cancer cells at low concentrations flowing in a microfluidic channel.ACS Nano2015;9: 4328–4336..

Gao YK, Gan QQ, Bartoli FJ. Breakthroughs in photonics 2013: research highlights on biosensors based on plasmonic nanostructures.IEEE Photonics J2014;6: 0700805..

Špačková B, Wrobel P, Bocková M, Homola J. Optical biosensors based on plasmonic nanostructures: a review.Proc IEEE2016;104: 2380–2408..

Jackman JA, Ferhan AR, Cho N-J. Nanoplasmonic sensors for biointerfacial science.Chem Soc Rev2017;46: 3615–3660..

Zhang Y, Zhen YR, Neumann O, Day JK, Nordlander Pet al. Coherent anti-stokes Raman scattering with single-molecule sensitivity using a plasmonic Fano resonance.Nat Commun2014;5: 4424..

Moore BD, Stevenson L, Watt A, Flitsch S, Turner NJet al. Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering.Nat Biotechnol2004;22: 1133–1138..

Punj D, Mivelle M, Moparthi SB, van Zanten TS, Rigneault Het al. A plasmonic 'antenna-in-box' platform for enhanced single-molecule analysis at micromolar concentrations.Nat Nanotechnol2013;8: 512–516..

Rodrigo D, Limaj O, Janner D, Etezadi D, de Abajo FJGet al. Mid-infrared plasmonic biosensing with graphene.Science2015;349: 165–168..

Kravets VG, Schedin F, Jalil R, Britnell L, Gorbachev RVet al. Singular phase nano-optics in plasmonic metamaterials for label-free single-molecule detection.Nat Mater2013;12: 304–309..

Homola J. Surface plasmon resonance sensors for detection of chemical and biological species.Chem Rev2008;108: 462–493..

Mazzotta F, Johnson TW, Dahlin AB, Shaver J, Oh S-Het al. Influence of the evanescent field decay length on the sensitivity of plasmonic nanodisks and nanoholes.ACS Photonics2015;2: 256–262..

Unser S, Bruzas I, He J, Sagle L. Localized surface plasmon resonance biosensing: current challenges and approaches.Sensors2015;15: 15684–15716..

Soler M, Belushkin A, Cavallini A, Kebbi-Beghddi C, Greub Get al. Multiplexed nanoplasmonic biosensor for one-step simultaneous detection ofChlamydia trachomatisandNeisseria gonorrhoeaein urine.Biosens Bioelectron2017;94: 560–567..

Yanik AA, Huang M, Kamohara O, Artar A, Geisbert TWet al. An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media.Nano Lett2010;10: 4962–4969..

Im H, Shao HL, Park YI, Peterson VM, Castro CMet al. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor.Nat Biotechnol2014;32: 490–495..

Yanik AA, Cetina AE, Huang M, Artara A, Mousavi SHet al. Seeing protein monolayers with naked eye through plasmonic Fano resonances.Proc Natl Acad Sci USA2011;108: 11784–11789..

Nayak S, Blumenfeld NR, Laksanasopin T, Sia SK. Point-of-care diagnostics: recent developments in a connected age.Anal Chem2017;89: 102–123..

Yager P, Domingo GJ, Gerdes J. Point-of-care diagnostics for global health.Annu Rev Biomed Eng2008;10: 107–144..

King K, Grazette LP, Paltoo DN, McDevitt JT, Sia SKet al. Point-of-care technologies for precision cardiovascular care and clinical research: national heart, lung, and blood institute working group.JACC Basic Transl Sci2016;1: 73–86..

Chocarro-Ruiz B, Fernández-Gavela A, Herranz S, Lechuga LM. Nanophotonic label-free biosensors for environmental monitoring.Curr Opin Biotechnol2017;45: 175–183..

Coskun AF, Cetin AE, Galarreta BC, Alvarez DA, Altug Het al. Lensfree optofluidic plasmonic sensor for real-time and label-free monitoring of molecular binding events over a wide field-of-view.Sci Rep2014;4: 6789..

Cetin AE, Coskun AF, Galarreta BC, Huang M, Herman Det al. Handheld high-throughput plasmonic biosensor using computational on-chip imaging.Light Sci Appl2014;3: e122, doi:10.1038/lsa.2014.3..

Cappi G, Spiga FM, Moncada Y, Ferretti A, Beyeler Met al. Label-free detection of tobramycin in serum by transmission-localized surface plasmon resonance.Anal Chem2015;87: 5278–5285..

Jahns S, Bräu M, Meyer B-O, Torben K, Gutekunst SBet al. Handheld imaging photonic crystal biosensor for multiplexed, label-free protein detection.Biomed Opt Express2015;6: 3724–3736..

Liu Y, Liu Q, Chen SM, Cheng F, Wang HQet al. Surface plasmon resonance biosensor based on smart phone platforms.Sci Rep2015;5: 12864..

Gallegos D, Long KD, Yu H, Clark PP, Lin YXet al. Label-free biodetection using a smartphone.Lab Chip2013;13: 2124–2132..

Kwon L, Long KD, Wan Y, Yu H, Cunningham BT. Medical diagnostics with mobile devices: comparison of intrinsic and extrinsic sensing.Biotechnol Adv2016;34: 291–304..

Ozcan A. Mobile phones democratize and cultivate next-generation imaging, diagnostics and measurement tools.Lab Chip2014;14: 3187–3194..

Nomarski MG. Microinterféromètre différentiel à ondes polarisées.J Phys Rad1955;16: S9–S13..

Zernike F. How I discovered phase contrast.Science1955;121: 345–349..

Wolf E. Solution of the phase problem in the theory of structure determination of crystals from X-ray diffraction experiments.Phys Rev Lett2009;103: 075501..

Carney PS, Deutsch B, Govyadinov AA, Hillenbrand R. Phase in nanooptics.ACS Nano2012;6: 8–12..

Kabashin AV, Nikitin PI. Interferometer based on a surface-plasmon resonance for sensor applications.Quantum Electron1997;27: 653..

Abelès F. Surface electromagnetic waves ellipsometry.Surf Sci1976;56: 237–251..

Huang YH, Ho HP, Kong SK, Kabashin AV. Phase-sensitive surface plasmon resonance biosensors: methodology, instrumentation andapplications.Ann Phys2012;524: 637–662..

Kabashin AV, Patskovsky S, Grigorenko AN. Phase and amplitude sensitivities in surface plasmon resonance bio and chemical sensing.Opt Express2009;17: 21191–21204..

Junesch J, Sannomiya T. Reflection phase and amplitude determination of short-range ordered plasmonic nanohole arrays.J Phys Chem Lett2014;5: 247–252..

Svedendahl M, Verre R, Käll M. Refractometric biosensing based on optical phase flips in sparse and short-range-ordered nanoplasmonic layers.Light Sci Appl2014;3: e220, doi:10.1038/lsa.2014.101..

Murphy DB, Davidson MW.Fundamentals of Light Microscopy and Electronic Imaging, 2nd edn. Chichester, UK: Wiley-Blackwell; 2013.

Ortega-Arroyo J, Kukura P. Interferometric scattering microscopy (iSCAT): new frontiers in ultrafast and ultrasensitive optical microscopy.Phys Chem Chem Phys2012;14: 15625–15636..

Liebel M, Hugall JT, van Hulst NF. Ultrasensitive label-free nanosensing and high-speed tracking of single proteins.Nano Lett2017;17: 1277–1281..

Terborg RA, Pello J, Mannelli I, Torres JP, Pruneri V. Ultrasensitive interferometric on-chip microscopy of transparent objects.Sci Adv2016;2: e1600077..

Ebbesen TW, Lezec HJ, Ghaemi HF, Thio T, Wolff PA. Extraordinary optical transmission through sub-wavelength hole arrays.Nature1998;391: 667–669..

Genet C, Ebbesen TW. Light in tiny holes.Nature2007;445: 39–46..

Cetin AE, Etezadi D, Galarreta BC, Busson MP, Eksioglu Yet al. Plasmonic nanohole arrays on a robust hybrid substrate for highly sensitive label-free biosensing.ACS Photonics2015;2: 1167–1174..

Jackman JA, Linardy E, Yoo D, Seo J, Ng WBet al. Plasmonic nanoholesensor for capturing single virus-like particles toward virucidal drug evaluation.Small2016;12: 1159–1166..

Wong SL, Ong HC. Phase difference mapping of two-dimensional metallic nanohole arrays.Appl Phys Lett2012;100: 233102..

Mojarad N, Fan D, Gobrecht J, Ekinci Y. Broadband interference lithography at extreme ultraviolet and soft X-ray wavelengths.Opt Lett2014;39: 2286–2289..

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰