Multispectral light scattering endoscopic imaging of esophageal precancer

Le Qiu; Ram Chuttani; Douglas K Pleskow; Vladimir Turzhitsky; Umar Khan; Yuri N Zakharov; Lei Zhang; Tyler M Berzin; Eric U Yee; Mandeep S Sawhney; Yunping Li; Edward Vitkin; Jeffrey D Goldsmith; Irving Itzkan; Lev T Perelman

doi:10.1038/lsa.2017.174

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Multispectral light scattering endoscopic imaging of esophageal precancer

Original Articles

- Multispectral light scattering endoscopic imaging of esophageal precancer
- Light: Science & Applications Vol. 7, Issue 3, (2018)
- Affiliations：
  
  1.Center for Advanced Biomedical Imaging and Photonics, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA
  2.Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA
  3.Department of Pathology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA
  4.Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA
  5.Biological and Biomedical Sciences Program, Harvard University, Boston, MA 02215, USA
- Author bio：
  
  LT Perelman, Email: lperelman@fas.harvard.edu
- Funds：
- DOI：10.1038/lsa.2017.174
  CLC：
- Published：2018，
  
  Published Online：06 April 2018，
  
  Received：13 July 2017，
  
  Revised：18 December 2017，
  
  Accepted：18 December 2017
- Accepted：
Scan QR Code
Qiu, L. et al. Multispectral light scattering endoscopic imaging of esophageal precancer. Light: Science & Applications, 7, 17174 (2018).
DOI：

Qiu, L. et al. Multispectral light scattering endoscopic imaging of esophageal precancer. Light: Science & Applications, 7, 17174 (2018). DOI： 10.1038/lsa.2017.174.

摘要

Abstract

Esophageal adenocarcinoma is the most rapidly growing cancer in America. Although the prognosis after diagnosis is unfavorable

the chance of a successful outcome increases tremendously if detected early while the lesion is still dysplastic. Unfortunately

the present standard-of-care

endoscopic surveillance

has major limitations

since dysplasia is invisible

often focal

and systematic biopsies typically sample less than one percent of the esophageal lining and therefore easily miss malignancies. To solve this problem we developed a multispectral light scattering endoscopic imaging system. It surveys the entire esophageal lining and accurately detects subcellular dysplastic changes. The system combines light scattering spectroscopy

which detects and identifies invisible dysplastic sites by analyzing light scattered from epithelial cells

with rapid scanning of the entire esophageal lining using a collimated broadband light beam delivered by an endoscopically compatible fiber optic probe. Here we report the results of the first comprehensive multispectral imaging study

conducted as part of routine endoscopic procedures performed on patients with suspected dysplasia. In a double-blind study that characterized the system's ability to serve as a screening tool

55 out of 57 patients were diagnosed correctly. In addition

a smaller double-blind comparison of the multispectral data in 24 patients with subsequent pathology at locations where 411 biopsies were collected yielded an accuracy of 90% in detecting individual locations of dysplasia

demonstrating the capability of this method to serve as a guide for biopsy.

关键词

Keywords

biophotonicsendoscopic multispectral imaginglight scattering spectroscopynoninvasive cancer detection

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