Localization optoacoustic tomography

X Luís Dean-Ben; Daniel Razansky

doi:10.1038/lsa.2018.4

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Localization optoacoustic tomography

Original Articles

- Localization optoacoustic tomography
- Light: Science & Applications Vol. 7, Issue 3, (2018)
- Affiliations：
  
  1.Institute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg 85764, Germany
  2.School of Medicine and School of Bioengineering, Technical University of Munich, Munich 81675, Germany
- Author bio：
  
  XL Dean-Ben, Email: xl.deanben@helmholtz-muenchen.de
- Funds：
- DOI：10.1038/lsa.2018.4
  CLC：
- Published：2018，
  
  Published Online：20 April 2018，
  
  Received：17 August 2017，
  
  Revised：12 January 2018，
  
  Accepted：14 January 2018
- Accepted：
Scan QR Code
Dean-Ben, X. L.& Razansky, D. et al. Localization optoacoustic tomography. Light: Science & Applications, 3, 18004 (2018).
DOI：

Dean-Ben, X. L.& Razansky, D. et al. Localization optoacoustic tomography. Light: Science & Applications, 3, 18004 (2018). DOI： 10.1038/lsa.2018.4.

摘要

Abstract

Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues. Herein

we introduce a new concept of localization optoacoustic tomography (LOT) that employs rapid sequential acquisition of three-dimensional optoacoustic images from flowing absorbing particles. We show that the new method enables breaking through the spatial resolution barrier of acoustic diffraction while further enhancing the visibility of structures under limited-view tomographic conditions. Given the intrinsic sensitivity of optoacoustics to multiple hemodynamic and oxygenation parameters

LOT may enable a new level of performance in studying functional and anatomical alterations of microcirculation.

关键词

Keywords

acoustic diffractionlimited-view effectslocalizationoptoacoustic imagingphotoacoustic imagingsuper-resolution

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