Ultrasonically sculpted virtual relay lens for in situ microimaging

Matteo Giuseppe Scopelliti; Maysamreza Chamanzar

doi:10.1038/s41377-019-0173-7

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Ultrasonically sculpted virtual relay lens for in situ microimaging

Article

- Ultrasonically sculpted virtual relay lens for in situ microimaging
- Light: Science & Applications Vol. 8, Issue 4, Pages: 565-579(2019)
- Affiliations：
  
  1.Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
  2.Carnegie Mellon Neuroscience Institute, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA
  3.Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 Forbes Avenue, Pittsburgh, PA 15213, USA
- Author bio：
  
  Maysamreza Chamanzar (mchamanzar@cmu.edu)
- Funds：
- DOI：10.1038/s41377-019-0173-7
  CLC：
- Published：2019，
  
  Published Online：17 July 2019，
  
  Received：01 February 2019，
  
  Revised：07 June 2019，
  
  Accepted：14 June 2019
- Accepted：
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Scopelliti, M. G. & Chamanzar, M. Ultrasonically sculpted virtual relay lens for in situ microimaging. Light: Science & Applications, 8, 565-579 (2019).
DOI：

Scopelliti, M. G. & Chamanzar, M. Ultrasonically sculpted virtual relay lens for in situ microimaging. Light: Science & Applications, 8, 565-579 (2019). DOI： 10.1038/s41377-019-0173-7.

摘要

Abstract

We demonstrate in situ non-invasive relay imaging through a medium without inserting physical optical components. We show that a virtual optical graded-index (GRIN) lens can be sculpted in the medium using in situ reconfigurable ultrasonic interference patterns to relay images through the medium. Ultrasonic wave patterns change the local density of the medium to sculpt a graded refractive index pattern normal to the direction of light propagation

which modulates the phase front of light

causing it to focus within the medium and effectively creating a virtual relay lens. We demonstrate the in situ relay imaging and resolving of small features (22 μm) through a turbid medium (optical thickness = 5.7 times the scattering mean free path)

which is normally opaque. The focal distance and the numerical aperture of the sculpted optical GRIN lens can be tuned by changing the ultrasonic wave parameters. As an example

we experimentally demonstrate that the axial focal distance can be continuously scanned over a depth of 5.4 mm in the modulated medium and that the numerical aperture can be tuned up to 21.5%. The interaction of ultrasonic waves and light can be mediated through different physical media

including turbid media

such as biological tissue

in which the ultrasonically sculpted GRIN lens can be used for relaying images of the underlying structures through the turbid medium

thus providing a potential alternative to implanting invasive endoscopes.

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references

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