
Institute of Nanophotonics, Jinan University, Guangzhou, 511443, China
Hongbao Xin (hongbaoxin@jnu.edu.cn)
Baojun Li (baojunli@jnu.edu.cn)
Published:31 July 2021,
Published Online:09 June 2021,
Received:22 March 2021,
Revised:10 May 2021,
Accepted:21 May 2021
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Pan, T. et al. Biophotonic probes for bio-detection and imaging. Light: Science & Applications, 10, 1185-1206 (2021).
Pan, T. et al. Biophotonic probes for bio-detection and imaging. Light: Science & Applications, 10, 1185-1206 (2021). DOI: 10.1038/s41377-021-00561-2.
The rapid development of biophotonics and biomedical sciences makes a high demand on photonic structures to be interfaced with biological systems that are capable of manipulating light at small scales for sensitive detection of biological signals and precise imaging of cellular structures. However
conventional photonic structures based on artificial materials (either inorganic or toxic organic) inevitably show incompatibility and invasiveness when interfacing with biological systems. The design of biophotonic probes from the abundant natural materials
particularly biological entities such as virus
cells and tissues
with the capability of multifunctional light manipulation at target sites greatly increases the biocompatibility and minimizes the invasiveness to biological microenvironment. In this review
advances in biophotonic probes for bio-detection and imaging are reviewed. We emphatically and systematically describe biological entities-based photonic probes that offer appropriate optical properties
biocompatibility
and biodegradability with different optical functions from light generation
to light transportation and light modulation. Three representative biophotonic probes
i.e.
biological lasers
cell-based biophotonic waveguides and bio-microlenses
are reviewed with applications for bio-detection and imaging. Finally
perspectives on future opportunities and potential improvements of biophotonic probes are also provided.
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