Color Cherenkov imaging of clinical radiation therapy

Daniel A. Alexander; Anthony Nomezine; Lesley A. Jarvis; David J. Gladstone; Brian W. Pogue; Petr Bruza

doi:10.1038/s41377-021-00660-0

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Color Cherenkov imaging of clinical radiation therapy

Articles

- Color Cherenkov imaging of clinical radiation therapy
- Light: Science & Applications Vol. 10, Issue 12, Pages: 2380-2386(2021)
- Affiliations：
  
  1.Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
  2.DoseOptics LLC, Lebanon, NH, USA
  3.Geisel School of Medicine, Dartmouth College, Hanover, NH, USA
  4.Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
- Author bio：
  
  Petr Bruza (Petr.Bruza@dartmouth.edu)
- Funds：
- DOI：10.1038/s41377-021-00660-0
  CLC：
- Published：31 December 2021，
  
  Published Online：04 November 2021，
  
  Received：06 July 2021，
  
  Revised：01 October 2021，
  
  Accepted：08 October 2021
- Accepted：
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Alexander D. A. et al. Color Cherenkov imaging of clinical radiation therapy. Light: Science & Applications, 10, 2380-2386 (2021).
DOI：

Alexander D. A. et al. Color Cherenkov imaging of clinical radiation therapy. Light: Science & Applications, 10, 2380-2386 (2021). DOI： 10.1038/s41377-021-00660-0.

摘要

Abstract

Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect

and this light is attenuated by tissue features as it leaves the body. In this study

a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume

oxygen saturation and major vessels within the body.

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Keywords

references

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