Unlocking the secrets of the invisible world: incredible deep optical imaging through in-silico clearing

Ting-Hui Xiao; Yuqi Zhou; Keisuke Goda

doi:10.1038/s41377-023-01199-y

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Unlocking the secrets of the invisible world: incredible deep optical imaging through in-silico clearing

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- Unlocking the secrets of the invisible world: incredible deep optical imaging through in-silico clearing
- Light: Science & Applications Vol. 12, Issue 8, Pages: 1439-1440(2023)
- Affiliations：
  
  1.Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450052, China
  2.Institute of Quantum Materials and Physics, Henan Academy of Sciences, Zhengzhou 450046, China
  3.Department of Chemistry, School of Science, The University of Tokyo, Tokyo 113-0033, Japan
  4.Institute of Technological Sciences, Wuhan University, Wuhan 430072, China
  5.Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
- Author bio：
  
  Keisuke Goda (goda@chem.s.u-tokyo.ac.jp)
- Funds：
- DOI：10.1038/s41377-023-01199-y
  CLC：
- Published：31 August 2023，
  
  Published Online：27 June 2023，
- Accepted：
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Xiao, T. H., Zhou, Y.Q. & Goda K. Unlocking the secrets of the invisible world: incredible deep optical imaging through in-silico clearing. Light: Science & Applications, 12, 1439-1440 (2023).
DOI：

Xiao, T. H., Zhou, Y.Q. & Goda K. Unlocking the secrets of the invisible world: incredible deep optical imaging through in-silico clearing. Light: Science & Applications, 12, 1439-1440 (2023). DOI： 10.1038/s41377-023-01199-y.

摘要

Abstract

In-silico clearing enables deep optical imaging of biological samples by correcting image blur caused by scattering and aberration. This breakthrough method offers researchers unprecedented insights into three-dimensional biological systems

with enormous potential for advancing biology and medicine to better understand living organisms and human health.

关键词

Keywords

references

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Yasuhiko, O.&Takeuchi, K. In-silico clearing approach for deep refractive index tomography by partial reconstruction and wave-backpropagation.Light Sci. Appl.12, 101 (2023)..

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Nishikawa, M. et al. Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19.Nat. Commun.12, 7135 (2021)..

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