Robotic pendant drop: containerless liquid for μs-resolved, AI-executable XPCS

Doga Yamac Ozgulbas; Don Jensen Jr.; Rory Butler; Rafael Vescovi; Ian T. Foster; Michael Irvin; Yasukazu Nakaye; Miaoqi Chu; Eric M. Dufresne; Soenke Seifert; Gyorgy Babnigg; Arvind Ramanathan; Qingteng Zhang

doi:10.1038/s41377-023-01233-z

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Robotic pendant drop: containerless liquid for μs-resolved, AI-executable XPCS

Original Articles

- Robotic pendant drop: containerless liquid for μs-resolved, AI-executable XPCS
- Light: Science & Applications Vol. 12, Issue 9, Pages: 1857-1866(2023)
- Affiliations：
  
  1.Data Science and Learning Division, Argonne National Laboratory, Lemont, IL 60439, USA
  2.X-ray Science Division, Argonne National Laboratory, Lemont, IL 60439, USA
  3.Departement of Computer Science, University of Chicago, 5801 S Ellis Ave, Chicago, IL 60637, USA
  4.XRD Design and Engineering Department, Rigaku Corporation 3-9-12 Matsubara-cho, Akishima-shi, Tokyo 196-8666, Japan
  5.Bioscience Division, Argonne National Laboratory, Lemont, IL 60439, USA
- Author bio：
  
  Arvind Ramanathan (ramanathana@anl.gov)
  Qingteng Zhang (qzhang234@anl.gov)
- Funds：
- DOI：10.1038/s41377-023-01233-z
  CLC：
- Published：30 September 2023，
  
  Published Online：18 August 2023，
  
  Received：29 January 2023，
  
  Revised：30 June 2023，
  
  Accepted：15 July 2023
- Accepted：
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Ozgulbas, D. Y. et al. Robotic pendant drop: containerless liquid for μs-resolved, AI-executable XPCS. Light: Science & Applications, 12, 1857-1866 (2023).
DOI：

Ozgulbas, D. Y. et al. Robotic pendant drop: containerless liquid for μs-resolved, AI-executable XPCS. Light: Science & Applications, 12, 1857-1866 (2023). DOI： 10.1038/s41377-023-01233-z.

摘要

Abstract

The dynamics and structure of mixed phases in a complex fluid can significantly impact its material properties

such as viscoelasticity. Small-angle X-ray Photon Correlation Spectroscopy (SA-XPCS) can probe the spontaneous spatial fluctuations of the mixed phases under various in situ environments over wide spatiotemporal ranges (10

−6

–10

s /10

−10

–10

−6

m). Tailored material design

however

requires searching through a massive number of sample compositions and experimental parameters

which is beyond the bandwidth of the current coherent X-ray beamline. Using 3.7-μs-resolved XPCS synchronized with the clock frequency at the Advanced Photon Source

we demonstrated the consistency between the Brownian dynamics of ~100 nm diameter colloidal silica nanoparticles measured from an enclosed pendant drop and a sealed capillary. The electronic pipette can also be mounted on a robotic arm to access different stock solutions and create complex fluids with highly-repeatable and precisely controlled composition profiles. This closed-loop

AI-executable protocol is applicable to light scattering techniques regardless of the light wavelength and optical coherence

and is a first step towards high-throughput

autonomous material discovery.

关键词

Keywords

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