Light-controlled soft bio-microrobot

Jianyun Xiong; Xing Li; Ziyi He; Yang Shi; Ting Pan; Guoshuai Zhu; Dengyun Lu; Hongbao Xin

doi:10.1038/s41377-024-01405-5

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Light-controlled soft bio-microrobot

Original Articles

- Light-controlled soft bio-microrobot
- Light: Science & Applications Vol. 13, Issue 3, Pages: 531-543(2024)
- Affiliations：
  
  Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Institute of Nanophotonics, Jinan University, 511443 Guangzhou, China
- Author bio：
  
  Hongbao Xin (hongbaoxin@jnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-024-01405-5
  CLC：
- Received：17 October 2023，
  
  Revised：29 January 2024，
  
  Accepted：2024-01-29，
  
  Published Online：26 February 2024，
  
  Published：31 March 2024
- Accepted：
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Xiong, J. Y. et al. Light-controlled soft bio-microrobot. Light: Science & Applications, 13, 531-543 (2024).
DOI：

Xiong, J. Y. et al. Light-controlled soft bio-microrobot. Light: Science & Applications, 13, 531-543 (2024). DOI： 10.1038/s41377-024-01405-5.

摘要

Abstract

Micro/nanorobots hold exciting prospects for biomedical and even clinical applications due to their small size and high controllability. However

it is still a big challenge to maneuver micro/nanorobots into narrow spaces with high deformability and adaptability to perform complicated biomedical tasks. Here

we report a light-controlled soft bio-microrobots (called "Ebot") based on

Euglena gracilis

that are capable of performing multiple tasks in narrow microenvironments including intestinal mucosa with high controllability

deformability and adaptability. The motion of the Ebot can be precisely navigated via light-controlled polygonal flagellum beating. Moreover

the Ebot shows highly controlled deformability with different light illumination duration

which allows it to pass through narrow and curved microchannels with high adaptability. With these features

Ebots are able to execute multiple tasks

such as targeted drug delivery

selective removal of diseased cells in intestinal mucosa

as well as photodynamic therapy. This light-controlled Ebot provides a new bio-microrobotic tool

with many new possibilities for biomedical task execution in narrow and complicated spaces where conventional t

ools are difficult to access due to the lack of deformability and bio-adaptability.

关键词

Keywords

references

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