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1.Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
2.Center for Systems Biology, Dresden 01307, Germany
3.Institute of Biological and Chemical Systems – Biological Information Processing. Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen 76344, Germany
4.Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK
Moritz Kreysing (moritz.kreysing@kit.edu)
Received:24 August 2023,
Revised:11 January 2024,
Accepted:2024-01-31,
Published Online:27 February 2024,
Published:31 March 2024
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Erben, E. et al. Opto-fluidically multiplexed assembly and micro-robotics. Light: Science & Applications, 13, 544-554 (2024).
Erben, E. et al. Opto-fluidically multiplexed assembly and micro-robotics. Light: Science & Applications, 13, 544-554 (2024). DOI: 10.1038/s41377-024-01406-4.
Techniques for high-definition micromanipulations
such as optical tweezers
hold substantial interest across a wide range of disciplines. However
their applicability remains constrained by material properties and laser exposure. And while microfluidic manipulations have been suggested as an alternative
their inherent capabilities are limited and further hindered by practical challenges of implementation and control. Here we show that the iterative application of laser-induced
localized flow fields can be used for the relative positioning of multiple micro-particles
irrespectively of their material properties. Compared to the standing theoretical proposal
our method keeps particles mobile
and we show that their precision manipulation is non-linearly accelerated via the multiplexing of temperature stimuli below the heat diffusion limit. The resulting flow fields are topologically rich and mathematically predictable. They represent unprecedented microfluidic control capabilities that are illustrated by the actuation of humanoid micro-robots with up to 30 degrees of freedom
whose motions are sufficiently well-defined to reliably communicate personal characteristics such as gender
happiness and nervousness. Our results constitute high-definition micro-fluidic manipulations with transformative potential for assembly
micro-manufacturing
the life sciences
robotics and opto-hydraulically actuated micro-factories.
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