
无数据
1.National Biomedical Imaging Center, College of Future Technology, Peking University, Beijing 100871, China
2.Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
Shuai Na (shuai@pku.edu.cn)
Published Online:07 May 2024,
Published:30 June 2024
Scan QR Code
Zheng, X. Y. & Na, S. A head-mounted photoacoustic fiberscope for hemodynamic imaging in mobile mice. Light: Science & Applications, 13, 1012-1014 (2024).
Zheng, X. Y. & Na, S. A head-mounted photoacoustic fiberscope for hemodynamic imaging in mobile mice. Light: Science & Applications, 13, 1012-1014 (2024). DOI: 10.1038/s41377-024-01454-w.
A miniaturized photoacoustic fiberscope has been developed
featuring a lateral resolution of 9 microns and a lightweight design at 4.5 grams. Engineered to capture hemodynamic processes at single-blood-vessel resolution at a rate of 0.2 Hz
this device represents an advancement in head-mounted tools for exploring intricate brain activities in mobile animals.
Raichle, M. E. & Mintun, M. A. Brain work and brain imaging. Annu. Rev. Neurosci. 29 , 449–476 (2006)..
Hall, C. N. et al. Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing. J. Neurosci. 32 , 8940–8951 (2012)..
Yao, J. J. et al. High-speed label-free functional photoacoustic microscopy of mouse brain in action. Nat. Methods 12 , 407–410 (2015)..
Yao, J. J. & Wang, L. V. Photoacoustic brain imaging: from microscopic to macroscopic scales. Neurophotonics 1 , 011003 (2014)..
Danielli, A. et al. Nonlinear photoacoustic spectroscopy of hemoglobin. Appl. Phys. Lett. 106 , 203701 (2015)..
Ashisha, G. R. et al. IoT-based continuous bedside monitoring systems. In: Advances in big data and cloud computing: proceedings of ICBDCC18 (eds. Peter, J. D., Alavi, A. H. & Javadi, B. ), 401–410 (Singapore: Springer, 2018).
Li, M. C., Tang, Y. Q. & Yao, J. J. Photoacoustic tomography of blood oxygenation: a mini review. Photoacoustics 10 , 65–73 (2018)..
Gao, Y. R. et al. Time to wake up: studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal. NeuroImage 153 , 382–398 (2017)..
Guo, C. L. et al. Miniscope-LFOV: a large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals. Sci. Adv. 9 , eadg3918 (2023)..
Li, H. Y. et al. Fast, volumetric live-cell imaging using high-resolution light-field microscopy. Biomed. Opt. Express 10 , 29–49 (2019)..
Mandracchia, B. et al. Fast and accurate sCMOS noise correction for fluorescence microscopy. Nat. Commun. 11 , 94 (2020)..
Zhao, W. S. et al. Enhanced detection of fluorescence fluctuations for high-throughput super-resolution imaging. Nat. Photonics 17 , 806–813 (2023)..
Guo, H. et al. Detachable head-mounted photoacoustic microscope in freely moving mice. Opt. Lett. 46 , 6055–6058 (2021)..
Zhong, X. X. et al. Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope. Light Sci. Appl. 13 , 5 (2024)..
Lee, W. & Roh, Y. Ultrasonic transducers for medical diagnostic imaging. Biomed. Eng. Lett. 7 , 91–97 (2017)..
Zheng, Q. C. et al. Thin ceramic PZT dual- and multi-frequency pMUT arrays for photoacoustic imaging. Microsyst. Nanoeng. 8 , 122 (2022)..
Wissmeyer, G. et al. Looking at sound:optoacoustics with all-optical ultrasound detection. Light Sci. Appl. 7 , 53 (2018)..
Hai, P. F. et al. Near-infrared optical-resolution photoacoustic microscopy. Opt. Lett. 39 , 5192–5195 (2014)..
0
Views
11
Downloads
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution
京公网安备11010802024621