Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo

Yang Lu; Xu Zhao; Dongmei Yan; Yingqian Mi; Peng Sun; Xu Yan; Xiaomin Liu; Geyu Lu

doi:10.1038/s41377-024-01539-6

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Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo

Original Articles

- Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo
- Light: Science & Applications Vol. 13, Issue 9, Pages: 1878-1887(2024)
- Affiliations：
  
  1.State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 130012 Changchun, China
  2.Department of Immunology, College of Basic Medical Sciences, Jilin University, 130021 Changchun, China
- Author bio：
  
  Xu Yan (yanx@jlu.edu.cn)
  Xiaomin Liu (xiaominliu@jlu.edu.cn)
  Geyu Lu (lugy@jlu.edu.cn)
- Funds：
- DOI：10.1038/s41377-024-01539-6
  CLC：
- Received：02 November 2023，
  
  Revised：19 June 2024，
  
  Accepted：2024-07-17，
  
  Published Online：01 August 2024，
  
  Published：30 September 2024
- Accepted：
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Lu, Y. et al. Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo. Light: Science & Applications, 13, 1878-1887 (2024).
DOI：

Lu, Y. et al. Upconversion-based chiral nanoprobe for highly selective dual-mode sensing and bioimaging of hydrogen sulfide in vitro and in vivo. Light: Science & Applications, 13, 1878-1887 (2024). DOI： 10.1038/s41377-024-01539-6.

摘要

Abstract

Chiral assemblies have become one of the most active research areas due to their versatility

playing an increasingly important role in bio-detection

imaging and therapy. In this work

chiral UCNPs/Cu

OS@ZIF nanoprobes are prepared by encapsulating upconversion nanoparticles (UCNPs) and Cu

OS nanoparticles (NPs) into zeolitic imidazolate framework-8 (ZIF-8). The novel excited-state energy distribution-modulated upconversion nanostructure (NaYbF

@NaYF

: Yb

Er) is selected as the fluorescence source and energy donor for highly efficient fluorescence resonance energy transfer (FRET). Cu

OS NP is employed as chiral source and energy acceptor to quench upconversion luminescence (UCL) and provide circular dichroism (CD) signal. Utilizing the natural adsorption and sorting advantages of ZIF-8

the designed nanoprobe can isolate the influence of other common disruptors

thus achieve ultra-sensitive and highly selecti

ve UCL/CD dual-mode quantification of H

S in aqueous solution and in living cells. Notably

the nanoprobe is also capable of in vivo intra-tumoral H

S tracking. Our work highlights the multifunctional properties of chiral nanocomposites in sensing and opens a new vision and idea for the preparation and application of chiral nanomaterials in biomedical and biological analysis.

关键词

Keywords

references

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