Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo

Jing Lv; Hengrong Lan; Aoji Qin; Tong Sun; Dan Shao; Fei Gao; Junjie Yao; Kamran Avanaki; Liming Nie

doi:10.1038/s41377-024-01644-6

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Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo

Original Articles

- Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo
- Light: Science & Applications Vol. 13, Issue 12, Pages: 3181-3195(2024)
- Affiliations：
  
  1.Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
  2.Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China
  3.School of Biomedical Engineering, Tsinghua University, Beijing 100084, China
  4.Department of PET Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China
  5.Hybrid Imaging System Laboratory, School of Information Science and Technology, ShanghaiTech University, Shanghai 201210, China
  6.Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
  7.Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA
- Author bio：
  
  Liming Nie (nieliming@gdph.org.cn)
- Funds：
- DOI：10.1038/s41377-024-01644-6
  CLC：
- Received：04 April 2024，
  
  Revised：29 August 2024，
  
  Accepted：2024-09-16，
  
  Published Online：31 October 2024，
  
  Published：31 December 2024
- Accepted：
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Lv, J. et al. Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo. Light: Science & Applications, 13, 3181-3195 (2024).
DOI：

Lv, J. et al. Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo. Light: Science & Applications, 13, 3181-3195 (2024). DOI： 10.1038/s41377-024-01644-6.

摘要

Abstract

Advancements in precision medicine necessitate understanding drug clearance pathways

especially in organs like the liver and kidneys. Traditional techniques such as PET/CT pose radiation hazards

whereas optical imaging poses challenges in maintaining both depth penetration and high resolution. Moreover

very few longitudinal studies have been performed for drug candidates for different symptoms. Leveraging non-ionizing photoacoustic tomography for deep tissue imaging

we developed a spatiotemporally resolved clearance pathway tracking (SRCPT) method

providing unprecedented insights into drug clearance dynamics within vital organs. SRCPT addresses challenges like laser fluence attenuation

enabling dynamic visualization of drug clearance pathways and essential parameter extraction. We employed a novel frequency component selection based synthetic aperture focusing technique (FCS-SAFT) with respiratory-artifacts-free weighting factors to enhance three-dimensional imaging resolutions. Inspired by this

we investigated the clearance pathway of a clinical drug

mitoxantrone

revealing reduced liver clearance when hepatic function is impaired. Furthermore

immunoglobulin G clearance analysis revealed significant differences among mice with varying renal injury degrees. The accuracy of our method was validated using a double-labeled probe [

]

DFO-IRDye800CW

showing a strong positive correlation between SRCPT and PET. We believe that this powerful SRCPT promises precise mapping of drug

clearance pathways and enhances diagnosis and treatment of liver and kidney-related diseases.

关键词

Keywords

references

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