A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy

Zhichao Wang; Yuqi Tang; Quan Li

doi:10.1038/s41377-024-01673-1

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A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy

Original Articles

- A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy
- Light: Science & Applications Vol. 14, Issue 1, Pages: 153-166(2025)
- Affiliations：
  
  1.Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China
  2.Materials Science Graduate Program, Kent State University, Kent, OH 44242, USA
- Author bio：
  
  Yuqi Tang (yqtang@seu.edu.cn)
  Quan Li (quanli3273@gmail.com)
- Funds：
- DOI：10.1038/s41377-024-01673-1
  CLC：
- Published：31 January 2025，
  
  Published Online：02 January 2025，
  
  Received：22 August 2024，
  
  Revised：19 October 2024，
  
  Accepted：2024-10-28
- Accepted：
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Wang, Z. C., Tang, Y. Q. & Li, Q. A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy. Light: Science & Applications, 14, 153-166 (2025).
DOI：

Wang, Z. C., Tang, Y. Q. & Li, Q. A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy. Light: Science & Applications, 14, 153-166 (2025). DOI： 10.1038/s41377-024-01673-1.

摘要

Abstract

The microenvironment of immunosuppression and low immunogenicity of tumor cells has led to unsatisfactory therapeutic effects of the currently developed nanoplatforms. Immunogenic cell death

such as pyroptosis and ferroptosis

can efficiently boost antitumor immunity. However

the exploration of nanoplatform for dual function inducers and combined immune activators that simultaneously trigger pyroptosis and ferroptosis remains limited. Herein

a multifunctional pH-responsive theranostic nanoplatform (M@P) is designed and constructed by self-assembly of aggregation-induced emission photosensitizer MTCN-3 and immunoadjuvant Poly(I: C)

which are further encapsulated in amphiphilic polymers. This nanoplatform is found to have the characteristics of cancer cell targeting

pH response

near-infrared fluorescence imaging

and lysosome targeting. Therefore

after targeting lysosomes

M@P can cause lysosome dysfunction through the generation of reactive oxygen species and heat under light irradiation

triggering pyroptosis and ferroptosis of tumor cells

achieving immunogenic cell death

and further enhancing immunotherapy through the combined effect with the immunoadjuvant Poly(I: C). The anti-tumor immunotherapy effect of M@P has been further demonstrated in in vivo antitumor experiment of 4T1 tumor-bearing mouse model with poor immunogenicity. This research would provide an impetus as well as a novel strategy for dual function inducers and combined immune activators enhanced photoimmunotherapy.

关键词

Keywords

references

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