Next generation drug clearance insights: real-time tracking in hepatobiliary and renal systems

Won Hur; Gi Hun Seong; Hak Soo Choi

doi:10.1038/s41377-025-01782-5

Your Location：

Home >

Browse articles >

Next generation drug clearance insights: real-time tracking in hepatobiliary and renal systems

News & Views

- Next generation drug clearance insights: real-time tracking in hepatobiliary and renal systems
- Light: Science & Applications Vol. 14, Issue 4, Pages: 873-876(2025)
- Affiliations：
  
  1.Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02124, USA
  2.Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan 426-791, South Korea
- Author bio：
  
  Gi Hun Seong (ghseong@hanyang.ac.kr)
  Hak Soo Choi (hchoi12@mgh.harvard.edu)
- Funds：
- DOI：10.1038/s41377-025-01782-5
  CLC：
- Published Online：26 February 2025，
  
  Published：30 April 2025
- Accepted：
Scan QR Code
Hur, W., Seong, G. H. & Choi, H. S. Next generation drug clearance insights: real-time tracking in hepatobiliary and renal systems. Light: Science & Applications, 14, 873-876 (2025).
DOI：

Hur, W., Seong, G. H. & Choi, H. S. Next generation drug clearance insights: real-time tracking in hepatobiliary and renal systems. Light: Science & Applications, 14, 873-876 (2025). DOI： 10.1038/s41377-025-01782-5.

摘要

Abstract

The integration of spatiotemporally resolved clearance pathway tracking (SRCPT) provides a new lens for evaluating drug clearance pathways

enabling precise mapping of physiological conditions of metabolic organs

such as liver or kidney impairment.

关键词

Keywords

references

Lv, J. et al. Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo. Light Sci. Appl. 13 , 304 (2024)..

Chen, R. H. et al. Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes. Nat. Nanotechnol. 16 , 455–465 (2021)..

Hyun, H. et al. 700-nm Zwitterionic near-infrared fluorophores for dual-channelimage-guided surgery. Mol. Imaging Biol. 18 , 52–61 (2016)..

Choi, H. S. et al. Renal clearance of quantum dots. Nat. Biotechnol. 25 , 1165–1170 (2007)..

Yang, C. G. et al. ZW800‐PEG: a renal clearable Zwitterionic near‐infrared fluorophore for potential clinical translation. Angew. Chem. 133 , 13966–13971 (2021)..

Ikeda, M. et al. Determination of renal function and injury using near-infrared fluorimetry in experimental cardiorenal syndrome. Am. J. Physiol. -Ren. Physiol. 312 , F629–F639 (2017)..

Kang, H. et al. Renal clearable nanochelators for iron overload therapy. Nat. Commun. 10 , 5134 (2019)..

Huang, Y. Y. et al. Physiological principles underlying the kidney targeting of renal nanomedicines. Nat. Rev. Nephrol. 20 , 354–370 (2024)..

Ahn, S. et al. Physicochemical descriptors in biodistribution and clearance of contrast agents. Adv. Photon. Res. 4 , 2300036 (2023)..

Du, B. J., Yu, M. X. & Zheng, J. Transport and interactions of nanoparticles in the kidneys. Nat. Rev. Mater. 3 , 358–374 (2018)..

Wasan, K. M. et al. Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nat. Rev. Drug Discov. 7 , 84–99 (2008)..

Owens, E. A. et al. Highly charged cyanine fluorophores for trafficking scaffold degradation. Biomed. Mater. 8 , 014109 (2013)..

Ciută, A. D. et al. Structure of human drug transporters OATP1B1 and OATP1B3. Nat. Commun. 14 , 5774 (2023)..

Arrese, M., Ananthananarayanan, M. & Suchy, F. J. Hepatobiliary transport: molecular mechanisms of development and cholestasis. Pediatr. Res. 44 , 141–147 (1998)..

Kellum, J. A. et al. Acute kidney injury. Nat. Rev. Dis. Prim. 7 , 52 (2021)..

Zhao, X. Y. et al. A rationally designed nuclei-targeting FAPI 04-based molecular probe with enhanced tumor uptake for PET/CT and fluorescence imaging. Eur. J. Nucl. Med. Mol. Imaging 51 , 1593–1604 (2024)..

Sajedi, S., Sabet, H. & Choi, H. S. Intraoperative biophotonic imaging systems for image-guided interventions. Nanophotonics 8 , 99–116 (2019)..

Choi, H. S. & Kim, H. K. Multispectral image-guided surgery in patients. Nat. Biomed. Eng. 4 , 245–246 (2020)..

Anderson, G. D. & Hakimian, S. Pharmacokin etic of antiepileptic drugs in patients with hepatic or renal impairment. Clin. Pharmacokinetics 53 , 29–49 (2014)..

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰