J-type assembled Pt(Ⅳ)-coordinated carbon dots for near-infrared light-triggered pyroptosis

Dongbo Guo; Yijie Hou; Qin Xu; Bingzhe Wang; Tesen Zhang; Quansheng Cheng; Maohua Chen; Linxuan Huang; Guichuan Xing; Songnan Qu

doi:10.1038/s41377-025-01834-w

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J-type assembled Pt(Ⅳ)-coordinated carbon dots for near-infrared light-triggered pyroptosis

Original Articles

- J-type assembled Pt(Ⅳ)-coordinated carbon dots for near-infrared light-triggered pyroptosis
- Light: Science & Applications Vol. 14, Issue 6, Pages: 1629-1642(2025)
- Affiliations：
  
  1.State key laboratory of digital medical engineering, Sanya Research Institute of Hainan University, School of Biomedical Engineering, Hainan University, Sanya 572025, China
  2.Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR 999067, China
  3.Dongguan Institute of Clinical Cancer Research, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), Dongguan 523109, China
- Author bio：
  
  Dongbo Guo (dongboguo@hainanu.edu.cn)
  Songnan Qu (songnanqu@um.edu.mo)
- Funds：
- DOI：10.1038/s41377-025-01834-w
  CLC：
- Received：10 December 2024，
  
  Revised：10 March 2025，
  
  Accepted：14 March 2025，
  
  Published Online：15 April 2025，
  
  Published：30 June 2025
- Accepted：
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Guo, D. B. et al. J-type assembled Pt(Ⅳ)-coordinated carbon dots for near-infrared light-triggered pyroptosis. Light: Science & Applications, 14, 1629-1642 (2025).
DOI：

Guo, D. B. et al. J-type assembled Pt(Ⅳ)-coordinated carbon dots for near-infrared light-triggered pyroptosis. Light: Science & Applications, 14, 1629-1642 (2025). DOI： 10.1038/s41377-025-01834-w.

摘要

Abstract

Near-infrared (NIR) light-triggered pyroptosis based on biocompatible Pt(Ⅳ)-coordinated nanomedicine for tumor precision therapy is challenging. Here

we disclose a supramolecular approach to construct a hollow-spherical supra-(carbon dots) (HS-Pt-CDs) via ultrasound-assisted J-type assembly of Pt(Ⅳ)-coordinated carbon dots (Pt-CDs). The peculiar assembling behaviors arise from the steric hindrance and lattice distortion in the bowl-like Pt-CDs caused by the coordination of Pt(Ⅳ) atoms among the sp

domains

which result in around 240 nm red-shifted absorption bands and promoting charge separation in the NIR region due to strong inter-molecular charge transfer (CT) in HS-Pt-CDs. The results reveal that HS-Pt-CDs exhibit excellent NIR light-activated photocatalytic capacities

involving the release of Pt(Ⅱ) species

the generation of hydroxyl radicals

and acidification under 690 nm laser irradiation. Combined with the effective cellular uptake and tumor accumulation

HS-Pt-CDs can efficiently trigger cancer cell pyroptosis under 690 nm laser irradiation

resulting in the destruction of the primary tumor and effectively induction of strong immunogenic cell death (ICD)

thereby evoking anti-tumor immune responses to suppress distant tumor and prevent cancer metastasis. Taken these merits

an important perspective of Pt(Ⅳ)-contained supra-CDs with outstanding NIR-triggered photocatalytic behaviors can be of great significance toward precision tumor phototherapy.

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references

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