Unlocking body-surface physiological evolution via IR-temperature dual sensing with single chalcogenide fiber

Yanqing Fu; Shiliang Kang; Gangjie Zhou; Xinxiang Huang; Linling Tan; Chengwei Gao; Shixun Dai; Changgui Lin

doi:10.1038/s41377-025-01840-y

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Unlocking body-surface physiological evolution via IR-temperature dual sensing with single chalcogenide fiber

Original Articles

- Unlocking body-surface physiological evolution via IR-temperature dual sensing with single chalcogenide fiber
- Light: Science & Applications Vol. 14, Issue 6, Pages: 1749-1758(2025)
- Affiliations：
  
  1.Laboratory of Infrared Materials and Devices, The Research Institute of Advanced Technologies, Ningbo University, Ningbo 315211, China
  2.Zhejiang Key Laboratory of Advanced Optical Functional Materials and Devices, Ningbo 315211, China
  3.Engineering Research Center for Advanced Infrared Photoelectric Materials and Devices of Zhejiang Province, Ningbo 315211, China
- Author bio：
  
  Shiliang Kang (kangshiliang@nbu.edu.cn)
  Changgui Lin (linchanggui@nbu.edu.cn)
- Funds：
- DOI：10.1038/s41377-025-01840-y
  CLC：
- Received：27 November 2024，
  
  Revised：13 March 2025，
  
  Accepted：19 March 2025，
  
  Published Online：25 April 2025，
  
  Published：30 June 2025
- Accepted：
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Fu, Y. Q. et al. Unlocking body-surface physiological evolution via IR-temperature dual sensing with single chalcogenide fiber. Light: Science & Applications, 14, 1749-1758 (2025).
DOI：

Fu, Y. Q. et al. Unlocking body-surface physiological evolution via IR-temperature dual sensing with single chalcogenide fiber. Light: Science & Applications, 14, 1749-1758 (2025). DOI： 10.1038/s41377-025-01840-y.

摘要

Abstract

Improvements to body-surface physiological monitoring ability including real-time

accuracy and integration

are essential to meet the

expansive demands for personal healthcare. As part of this

simultaneous monitoring of sweat metabolites and body temperature offers an exciting path to maximizing diagnostic precision and minimizing morbidity rates. Herein

we report a high-performance biomarker-temperature sensor made of a single As

chalcogenide glass fiber to monitor physiology evolution on body-surface. The sensor integrates efficient thermal resistance and fiber evanescent wave effects

permitting the independent sensing of temperature and biomarkers with an ultrahigh temperature coefficient of resistance (−5.84% K

–1

)

rapid temperature response (0.3 s) and excellent IR sensing sensitivity. Moreover

by attaching a fiber to the wrist

we demonstrate simultaneous observation of both sweat metabolite (urea and lactate) and temperature changes during exercise. This illuminating sensing method will provide crucial capabilities in physiological monitoring and pave the way for advanced personalized diagnostic.

关键词

Keywords

references

Tu, J. B. et al. A wireless patch for the monitoring of C-reactive protein in sweat. Nat. Biomed. Eng. 7 , 1293–1306 (2023)..

Liu, T. L. et al. Battery-free, tuning circuit–inspired wireless sensor systems for detection of multiple biomarkers in bodily fluids. Sci. Adv. 8 , eabo7049 (2022)..

Cazanave, S. C. et al. Peptide-based urinary monitori ng of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors. Sci. Transl. Med. 13 , eabe8939 (2021)..

Xu, Y. C. et al. In-ear integrated sensor array for the continuous monitoring of brain activity and of lactate in sweat. Nat. Biomed. Eng. 7 , 1307–1320 (2023)..

Ates, H. C. et al. End-to-end design of wearable sensors. Nat. Rev. Mater. 7 , 887–907 (2022)..

He, X. Y. et al. A waterproof, environment‐friendly, multifunctional, and stretchable thermoelectric fabric for continuous self‐powered personal health signal collection at high humidity. SusMat 3 , 709–720 (2023)..

Nakata, S. et al. Wearable, flexible, and multifunctional healthcare device with an ISFET chemical sensor for simultaneous sweat pH and skin temperature monitoring. ACS Sens. 2 , 443–448 (2017)..

Tong, X. L. et al. Multifunctional fiber for synchronous bio‐sensing and power supply in sweat environment. Adv. Funct. Mater. 33 , 2301174 (2023)..

Sang, M. Y. et al. Ultrahigh sensitive Au‐doped silicon nanomembrane ba sed wearable sensor arrays for continuous skin temperature monitoring with high precision. Adv. Mater. 34 , 2105865 (2022)..

Su, Y. et al. Printable, highly sensitive flexible temperature sensors for human body temperature monitoring: a review. Nanoscale Res. Lett. 15 , 200 (2020)..

Li, F. C. et al. Printable and stretchable temperature-strain dual-sensing nanocomposite with high sensitivity and perfect stimulus discriminability. Nano. Lett. 20 , 6176–6184 (2020)..

Lu, Y. F. et al. Robust fiber‐shaped flexible temperature sensors for safety monitoring with ultrahigh sensitivity. Adv. Mater. 36 , 2310613 (2024)..

Zhao, X. F. et al. A fully flexible intelligent thermal touch panel based on intrinsically plastic Ag 2 S semiconductor. Adv. Mater. 34 , 2107479 (2022)..

Gao, W. et al. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature 529 , 509–514 (2016)..

Torrente-Rodríguez, R. M. et al. Investigation of cortisol dynamics in human sweat using a graphene-based wireless mHealth system. Matter 2 , 921–937 (2020)..

Mukasa, D. et al. A computationally assisted approach for designing wearable biosensors toward non‐invasive personalized molecular analysis. Adv. Mater. 35 , 2212161 (2023)..

Wang, M. Q. et al. A wearable electrochemical biosensor for the monitoring of metabolites and nutrients. Nat. Biomed. Eng. 6 , 1225–1235 (2022)..

Yang, Y. R. et al. A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat. Nat. Biotechnol. 38 , 217–224 (2020)..

Yue, X. P. et al. Simple, skin-attachable, and multifunctional colorimetric sweat sensor. ACS Sens. 7 , 2198–2208 (2022)..

Gao, W. et al. Flexible electronics toward wearable sensing. Acc. Chem. Res. 52 , 523–533 (2019)..

Tan, Q. et al. Polished hollow core Bragg fiber sensor for simultaneous measurement of cortisol concentration and temperature. Opt. Express 31 , 25662–25679 (2023)..

Zhao, Y. et al. Review of wearable optical fiber sensors: drawing a blueprint for human health monitoring. Opt. Laser Technol. 161 , 109227 (2023)..

Min, J. H. et al. Skin-interfaced wearable sweat sensors for precision medicine. Chem. Rev. 123 , 5049–5138 (2023)..

Gao, F. P. et al. Wearable and flexible electrochemical sensors for sweat analysis: a review. Microsyst. Nanoeng. 9 , 1 (2023)..

Chung, M., Fortunato, G. & Radacsi, N. Wearable flexible sweat sensors for healthcare monitoring: A review. J. R. Soc. Interface 16 , 20190217 (2019)..

Kaya, T. et al. Wearable sweat sensors: background and current trends. Electroanalysis 31 , 411–421 (2019)..

Wang, B. T. & Wang, Q. An interferometric optical fiber biosensor with high sensitivity for IgG/anti-IgG immunosensing. Opt. Commun. 426 , 388–394 (2018)..

Mondal, D. et al. Rapid and efficient identification of Cd (Ⅱ) ions in water with funct ionalized gold nanoparticle coated etched FBG sensors. IEEE Sens. J. 24 , 28852–28859 (2024)..

Zhao, Y. K. et al. Infrared tapered fiber ring sensor for environmental detection of organic pollutants. Sens. Actuators B: Chem. 405 , 135361 (2024)..

Gervillié-Mouravieff, C. et al. Unlocking cell chemistry evolution with operando fibre optic infrared spectroscopy in commercial Na(Li)-ion batteries. Nat. Energy 7 , 1157–1169 (2022)..

Zhou, Y. H. et al. Non-destructive and in-situ detection of shrimp freshness using mid-infrared fiber-optic evanescent wave spectroscopy. Food Chem. 422 , 136189 (2023)..

Srinivasan, B. et al. Thermoelectric properties of highly-crystallized Ge-Te-Se glasses doped with Cu/Bi. Materials 10 , 328 (2017)..

Bayindir, M. et al. Thermal‐sensing fiber devices by multimaterial codrawing. Adv. Mater. 18 , 845–849 (2006)..

Wang, X. M. et al. High-sensitivity sensing in bare Ge-Sb-Se chalcogenide tapered fiber withoptimal structure parameters. J. Non-Crystalline Solids 559 , 120686 (2021)..

You, T. X. et al. An infrared evanescent wave sensor for detection of ascorbic acid in food and drugs. J. Lightwave Technol. 42 , 3494–3500 (2024)..

Cui, S. et al. Te-based glass fiber for far-infrared biochemical sensing up to 16 μm. Opt. Express 22 , 21253–21262 (2014)..

Cui, S. et al. Selenide and telluride glasses for mid-infrared bio-sensing. Proceedings of SPIE 8938, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV. San Francisco, California, United States: SPIE, 2014.

Mytilineou, E. & Roilos, M. Dependence of the Hall mobility on composition in As 2 (S, Se, Te) 3 glasses. Philos. Mag. B 37 , 387–396 (1978)..

Roilos, M. Conductivity and hall effect in vitreous As 2 (Se, Te) 3 . J. Non-Crystalline Solids 6 , 5–12 (1971)..

Yeon, H. et al. Long-termreliable physical health monitoring by sweat pore–inspired perforated electronic skins. Sci. Adv. 7 , eabg8459 (2021)..

Zhong, B. W. et al. Wearable sweat loss measuring devices: from the role of sweat loss to advanced mechanisms and designs. Adv. Sci. 9 , 2103257 (2022)..

Jiang, X. & Jha, A. Engineering of a Ge-Te-Se glass fibre evanescent wave spectroscopic (FEWS) mid-IR chemical sensor for the analysis of food and pharmaceutical products. Sens. Actuators B: Chem. 206 , 159–169 (2015)..

Chen, Y. K. et al. Transmission FT-IR study on the adsorption and reactions of lactic acid and poly (lactic acid) on TiO 2 . J. Phys. Chem. C. 114 , 17720–17727 (2010)..

Qiao, Y. T. et al. Wearable sensor for continuous sweat biomarker monitoring. Chemosensors 10 , 273 (2022)..

Caixeta, D. C. et al. Monitoring glucose levels inurine using FTIR spectroscopy combined with univariate and multivariate statistical methods. Spectrochimica Acta Part A: Mol. Biomol. Spectrosc. 290 , 122259 (2023)..

Grdadolnik, J. & Maréchal, Y. Urea and urea–water solutions-an infrared study. J. Mol. Struct. 615 , 177–189 (2002)..

Charpentier, F. et al. Infrared monitoring of underground CO 2 storage using chalcogenide glass fibers. Opt. Mater. 31 , 496–500 (2009)..

Lucas, P. et al. Infrared biosensors using hydrophobic chalcogenide fibers sensitized with live cells. Sens. Actuators B: Chem. 119 , 355–362 (2006)..

Komkova, M. A. et al. Simultaneous monitoring of sweat lactate content and sweat secretion rate by wearable remote biosensors. Biosens. Bioelectron. 202 , 113970 (2022)..

Xuan, X. et al. Lactate biosensing for reliable on-body sweat analysis. ACS Sens. 6 , 2763–2771 (2021)..

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