Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography

Pavel V. Subochev; Xosé Luís Deán-Ben; Zhenyue Chen; Maxim B. Prudnikov; Vladimir A. Vorobev; Alexey A. Kurnikov; Anna G. Orlova; Anna S. Postnikova; Alexey V. Kharitonov; Mikhail D. Proyavin; Roman I. Ovsyannikov; Anatoly G. Sanin; Mikhail Y. Kirillin; Francisco Montero de Espinosa; Ilya V. Turchin; Daniel Razansky

doi:10.1038/s41377-025-01894-y

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Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography

Original Articles

- Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography
- Light: Science & Applications Vol. 14, Issue 9, Pages: 2489-2502(2025)
- Affiliations：
  
  1.Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod, Russia
  2.Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, Switzerland
  3.Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich, Switzerland
  4.Instituto de Tecnologías Físicas y de la Información—CSIC, Madrid, Spain
  5.Institute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany
  6.Present address: Institute of Precision Optical Engineering, School of Physics Science and Engineering, Tongji University, Shanghai, China
- Author bio：
  
  Pavel V. Subochev (pavel.subochev@gmail.com)
  Daniel Razansky (daniel.razansky@uzh.ch)
- Funds：
- DOI：10.1038/s41377-025-01894-y
  CLC：
- Received：16 June 2024，
  
  Revised：2025-04-15，
  
  Accepted：16 May 2025，
  
  Published Online：07 July 2025，
  
  Published：30 September 2025
- Accepted：
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Subochev, P.V. et al. Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography. Light: Science & Applications, 14, 2489-2502 (2025).
DOI：

Subochev, P.V. et al. Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography. Light: Science & Applications, 14, 2489-2502 (2025). DOI： 10.1038/s41377-025-01894-y.

摘要

Abstract

Owing to its unique ability to capture volumetric tomographic information with a single light flash

optoacoustic (OA) tomography has recently demonstrated ultrafast imaging speeds ultimately limited by the ultrasound time-of-flight. The method's scalability and the achievable spatial resolution are yet limited by the narrow bandwidth of piez

o-composite arrays currently employed for OA signal detection. Here we report on the first implementation of high-density spherical array technology based on flexible polyvinylidene difluoride films featuring ultrawideband (0.3–40 MHz) sub mm

area elements

thus enabling real-time multi-scale volumetric imaging with 22–35 µm spatial resolution

superior image fidelity and over an order of magnitude signal-to-noise enhancement compared to piezo-composite equivalents. We further demonstrate five-dimensional (spectroscopic

time-resolved

volumetric) imaging capabilities by visualizing fast stimulus-evoked cerebral oxygenation changes in mice and performing real-time functional angiography of deep human micro-vasculature. The new technology thus leverages the true potential of OA for quantitative high-resolution visualization of rapid bio-dynamics across scales.

关键词

Keywords

references

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