Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE)

Daixuan Wu; Yuecheng Shen; Zhongzheng Zhu; Tijian Li; Jiawei Luo; Zhengyang Wang; Jiaming Liang; Zhiling Zhang; Yunhua Yao; Dalong Qi; Lianzhong Deng; Zhenrong Sun; Meng Liu; Zhi-Chao Luo; Shian Zhang

doi:10.1038/s41377-025-01931-w

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Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE)

Original Articles

- Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE)
- Light: Science & Applications Vol. 14, Issue 9, Pages: 2752-2763(2025)
- Affiliations：
  
  1.Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, Guangdong 510006, China
  2.State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China
  3.School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou 510006, China
  4.MOE Key Laboratory of Laser Life Science, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510631, China
  5.Joint Research Center of Light Manipulation Science and Photonic Integrated Chip of East China Normal University and Shandong Normal University, East China Normal University, Shanghai 200241, China
  6.Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, China
- Author bio：
  
  Yuecheng Shen (ycshen@lps.ecnu.edu.cn)
  Zhi-Chao Luo (zcluo@scnu.edu.cn)
  Shian Zhang (sazhang@phy.ecnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-025-01931-w
  CLC：
- Received：02 December 2024，
  
  Revised：2025-05-22，
  
  Accepted：21 June 2025，
  
  Published Online：11 August 2025，
  
  Published：30 September 2025
- Accepted：
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Wu, D X. et al. Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE). Light: Science & Applications, 14, 2752-2763 (2025).
DOI：

Wu, D X. et al. Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE). Light: Science & Applications, 14, 2752-2763 (2025). DOI： 10.1038/s41377-025-01931-w.

摘要

Abstract

Single-pixel imaging (SPI) is a promising technology for optical imaging beyond the visible spectrum

where commercial cameras are expen

sive or unavailable. However

limitations such as slow pattern projection rates and time-consuming reconstruction algorithms hinder its throughput for real-time imaging. Consequently

conventional SPI is inadequate for high-speed

high-resolution tasks. To address these challenges

we developed an ultrahigh-throughput single-pixel complex-field microscopy (SPCM) system utilizing frequency-comb acousto-optic coherent encoding (FACE). This system enables real-time complex-field monitoring in the non-visible domain. Operating at 1030 nm

our system achieves a record-high space-bandwidth-time product (SBP-T) of 1.3 × 10

surpassing previous SPCM (~10

)

SPI (~10

)

and even certain types of commercial near-infrared cameras (~10

). It supports real-time streaming at 1000 Hz with a frame size of 80 × 81 pixels and a lateral resolution of 3.76 μm across an approximately 300 μm field of view. We validated the system by imaging dynamic transparent scenes

including microfluidics

live microorganisms

chemical reactions

as well as imaging through scattering media. This advancement offers a superior solution for high-speed

high-resolution complex-field imaging beyond the visible spectrum

significantly enhancing SPI performance across various applications.

关键词

Keywords

references

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