Water-insensitive down-shifting nanoparticles for sensitive biosensing

Jiang Ming; Sikun Hu; Fan Zhang

doi:10.1038/s41377-025-01976-x

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Water-insensitive down-shifting nanoparticles for sensitive biosensing

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- Water-insensitive down-shifting nanoparticles for sensitive biosensing
- Light: Science & Applications Vol. 14, Issue 10, Pages: 2868-2870(2025)
- Affiliations：
  
  Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University, Shanghai 200433, China
- Author bio：
  
  Fan Zhang (zhang_fan@fudan.edu.cn)
- Funds：
- DOI：10.1038/s41377-025-01976-x
  CLC：
- Published Online：05 September 2025，
  
  Published：31 October 2025
- Accepted：
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Ming, J., Hu, S. K. & Zhang, F. Water-insensitive down-shifting nanoparticles for sensitive biosensing. Light: Science & Applications, 14, 2868-2870 (2025).
DOI：

Ming, J., Hu, S. K. & Zhang, F. Water-insensitive down-shifting nanoparticles for sensitive biosensing. Light: Science & Applications, 14, 2868-2870 (2025). DOI： 10.1038/s41377-025-01976-x.

摘要

Abstract

Conventional optical probes suffer from signal degradation in aqueous media

hindering sensitive biodetection. To overcome this

newly developed water-insensitive down-shifting nanoparticles (WINPs) possess superior photophysical properties in the NIR-Ⅰ window

including high quantum yield and negligible thermal effects

permitting stable

high-contrast signal generation under low excitation power. This advantage facilitated a low-power lateral flow assay capable of highly sensitive avian influenza virus (AIV) detection in the opaque biological matrices (such as avian swabs)

mitigating interference issues relying on visible-range signals.

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Keywords

references

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