Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy

Min Gu; Hongchun Bao; Xiaosong Gan; Nicholas Stokes; Jingzhi Wu

doi:10.1038/lsa.2014.7

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Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy

Original Articles

- Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy
- Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy
- LSA 2014年3卷第1期
- Affiliations：
  
  Centre for Micro-Photonics, Faculty of Engineering & Industrial Sciences, Swinburne University of Technology, Hawthorn, Vic. 3122, Australia
- Author bio：
  
  Dr M Gu, Centre for Micro-Photonics, Faculty of Engineering & Industrial Sciences, Swinburne University of Technology, Hawthorn, Vic. 3122, Australia Email: mgu@swin.edu.au
- Funds：
- DOI：10.1038/lsa.2014.7
  中图分类号：
- 纸质出版日期：2014-03，
  
  网络出版日期：2014-01-03，
  
  收稿日期：2013-04-18，
  
  修回日期：2013-07-24，
  
  录用日期：2013-08-29
- Accepted：
Scan QR Code
Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy[J]. LSA, 2014,3(1).

Gu, M. et al. Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy. Light: Science & Applications, 3, e126 (2014).
Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy[J]. LSA, 2014,3(1). DOI： 10.1038/lsa.2014.7.

Gu, M. et al. Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy. Light: Science & Applications, 3, e126 (2014). DOI： 10.1038/lsa.2014.7.

摘要

Abstract

The precise control and manipulation of micro- and nanoparticles using an optical endoscope are potentially important in biomedical studies

bedside diagnosis and treatment in an aquatic internal organ environment

but they have not yet been achieved. Here

for the first time

we demonstrate optical nonlinear endoscopic tweezers (ONETs) for directly controlling and manipulating aquatic micro- and nanobeads as well as gold nanorods. It is found that two-photon absorption can enhance the trapping force on fluorescent nanobeads by up to four orders of magnitude compared with dielectric nanobeads of the same size. More importantly

two-photon excitation leads to a plasmon-mediated optothermal attracting force on nanorods

which can extend far beyond the focal spot. This new phenomenon facilitates a snowball effect that allows the fast uploading of nanorods to a targeted cell followed by thermal treatment within 1 min. As two-photon absorption allows an operation wavelength at the center of the transmission window of human tissue

our work demonstrates that ONET is potentially an unprecedented tool for precisely specifying the location and dosage of drug particles and for rapidly uploading metallic nanoparticles to individual cancer cells for treatment.

关键词

Keywords

endoscopygold nanorodsmicro/nanotweezingtwo-photon absorption

references

Ashkin A. Acceleration and trapping of particles by radiation pressure.Phys Rev Lett1970;24: 156–159..

Ashkin A, Dziedzic JM. Optical trapping and manipulation of viruses and bacteria.Science1987;235: 1517–1520..

MacDonald MP, Spalding GC, Dholakia K. Microfluidic sorting in an optical lattice.Nature2003;426: 421–424..

Hubbell JA. Enhancing drug function.Science2003;300: 595–596..

Huang XH, El-Sayed IH, Qian W, El-Sayed MA. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods.J Am Chem Soc2006;128: 2115–2120..

Gu M, Bao H, Li JL. Cancer-cell microsurgery using nonlinear optical endomicroscopy.J Biomed Opt2010;15: 050502..

Durr NJ, Larson T, Smith DK, Korgel BA, Sokolov Ket al. Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods.Nano Lett2007;7: 941–945..

Lyubin EV, Khokhlova MD, Skryabina MN, Fedyanin AA. Cellular viscoelasticity probed by active rheology in optical tweezers.J Biomed Opt2012;17: 101510..

Chung HS, McHale K, Louis JM, Eaton WA. Single-molecule fluorescence experiments determine protein folding transition path time.Science2012;335: 981–984..

Ashkin A. Applications of laser radiation pressure.Science1980;210: 1081–1088..

Moffitt JR, Chemla YR, Izhaky D, Bustamante C. Differential detection of dual traps improves the spatial resolution of optical tweezers.Proc Natl Acad Sci USA2006;103: 9006–9011..

Zhang W, Huang L, Santschi C, Martin OJ. Trapping and sensing 10 nm metal nanoparticles using plasmonic dipole antennas.Nano Lett2010;10: 1006–1011..

Neuman KC, Block SM. Optical trapping.Rev Sci Instrum2004;75: 2787–2809..

Flusberg BA, Cocker ED, Piyawattanametha W, Jung JC, Cheung ELet al. Fiber-optic fluorescence imaging.Nat Methods2005;2: 941–950..

Bao H, Allen J, Pattie R, Vance R, Gu M. A fast handhold two-photon fluorescence micro-endoscope with a 475 µm×475 µm field of view forin vivoimaging.Opt Lett2008;33: 1333–1335..

Cizmar T, Dholakia K. Shaping the light transmission through a multimode optical fibre: complex transformation analysis and applications.Opt Express2011;19: 18871–18884..

Konig K, Ethlers A, Riemann I, Schenkl S, Buckle Ret al. Clinical two-photon microendoscopy.Micros Res Tech2007;70: 398–402..

Ganic D, Gan X, Gu M. Optical trapping force with annular and doughnut laser beams based on vectorial diffraction.Opt Express2005;13: 1260–1265..

Liu Y, Sonek YG, Berns MW, Konig K, Tromberg B. Two-photon fluorescence excitation in continuous wave infrared optical tweezers.Opt Lett1995;20: 2246–2248..

Agate B, Brown CT, Sibbett W, Dholakia K. Femtosecond optical tweezers forin-situcontrol of two-photon fluorescence.Opt Express2004;12: 3011–3017..

Morrish D, Gan X, Gu M. Morphology-dependent resonance induced by two-photon excitation in a micro-sphere trapped by a femtosecond pulsed laser.Opt Express2004;12: 4198–4202..

Wang HF, Huff TB, Zweifel DA, He W, Low PSet al.In vitroandin vivotwo-photon luminescence imaging of single gold nanorods.Proc Natl Acad Sci USA2005;102: 15752–15756..

Li JL, Day D, Gu M. Ultra-low energy threshold for cancer photothermal therapy using transferrin-conjugated cold nanorods.Adv Mater2008;20: 3866–3871..

Wu J, Gan X. Optimization of plasmonic nanostructure for nanoparticle trapping.Opt Express2012;20: 14879–14890..

Dienerowitz M, Mazilu M, Reece PJ, Krauss TF, Dholakia K. Optical vortex trap for resonant confinement of metal nanoparticles.Opt Express2008;16: 4991–4999..

Furukawa H, Yamaguchi I. Optical trapping of metallic particles by a fixed Gaussian beam.Opt Lett1998;23: 216–218..

Gu M, Ke PC. Image enhancement in near-field scanning optical microscopy with laser-trapped metallic particles.Opt Lett1999;24: 74–76..

Gu M.Advanced Optical Imaging Theory. Heidelberg: Springer; 2000.

Zelenina A, Quidant R, Nieto-Vesperinas M. Enhanced optical forces between coupled resonant metal nanoparticles.Opt Lett2007;32: 1156–1158..

Jiang Y, Narushima T, Okamoto H. Nonlinear optical effects in trapping nanoparticles with femtosecond pulses.Nat Phys2010;6: 1005–1009..

Xin H, Li X, Li B. Massive photothermal trapping and migration of particles by a tapered optical fiber.Opt Express2011;19: 17065–17074..

Deng H, Li G, Dai Q, Ouyang M, Lan Set al. Role of interfering optical fields in the trapping and melting of gold nanorods and related clusters.Opt Express2012;20: 10963–10970..

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