Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules

Hyukjin Jung; Moonseong Park; Minhee Kang; Ki-Hun Jeong

doi:10.1038/lsa.2016.9

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Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules

Original Articles

- Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules
- Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules
- LSA 2016年5卷第1期
- Affiliations：
  
  Department of Bio and Brain Engineering, KAIST Institute for Optical Science and Technology, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Korea
- Author bio：
  
  KH Jeong, Email: kjeong@kaist.ac.kr
- Funds：
- DOI：10.1038/lsa.2016.9
  中图分类号：
- 纸质出版日期：2016-03，
  
  网络出版日期：2015-08-23，
  
  收稿日期：2015-03-08，
  
  修回日期：2015-08-11，
  
  录用日期：2015-08-17
- Accepted：
Scan QR Code
Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules[J]. LSA, 2016,5(1).

Jung, H. et al. Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules. Light: Science & Applications, 5, e16009 (2016).
Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules[J]. LSA, 2016,5(1). DOI： 10.1038/lsa.2016.9.

Jung, H. et al. Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules. Light: Science & Applications, 5, e16009 (2016). DOI： 10.1038/lsa.2016.9.

摘要

Abstract

High-throughput small-molecule assays play essential roles in biomedical diagnosis

drug discovery

environmental analysis

and physiological function research. Nanoplasmonics holds a great potential for the label-free detection of small molecules at extremely low concentrations. Here

we report the development of nanoplasmonic paper (NP-paper) for the rapid separation and ultrasensitive detection of mixed small molecules. NP-paper employs nanogap-rich silver nanoislands on cellulose fibers

which were simply fabricated at the wafer level by using low-temperature solid-state dewetting of a thin silver film. The nanoplasmonic detection allows for the scalable quantification and identification of small molecules over broad concentration ranges. Moreover

the combination of chromatographic separation and nanoplasmonic detection allows both the highly sensitive fluorescence detection of mixed small molecules at the attogram level and the label-free detection at the sub-nanogram level based on surface-enhanced Raman scattering. This novel material provides a new diagnostic platform for the high-throughput

low-cost

and label-free screening of mixed small molecules as an alternative to conventional paper chromatography.

关键词

Keywords

nanoplasmonicspaper chromatographyplasmon-enhanced spectroscopysilver nanoislandssmall-molecule assay

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