Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

Filiz Yesilkoy; Roland A Terborg; Josselin Pello; Alexander A Belushkin; Yasaman Jahani; Valerio Pruneri; Hatice Altug

doi:10.1038/lsa.2017.152

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Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

Original Articles

- Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager
- Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager
- LSA 2018年7卷第2期
- Affiliations：
  
  1.Institute of BioEngineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
  2.ICFO—Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain
  3.ICREA—Institució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain
- Author bio：
  
  V Pruneri, E-mail: valerio.pruneri@icfo.eu
  H Altug, E-mail: hatice.altug@epfl.ch
- Funds：
- DOI：10.1038/lsa.2017.152
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2018-02-23，
  
  收稿日期：2017-08-22，
  
  修回日期：2017-10-26，
  
  录用日期：2017-10-27
- Accepted：
Scan QR Code
Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager[J]. LSA, 2018,7(2):17152-9.

Yesilkoy, F. et al. Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager. Light: Science & Applications, 7, 17152 (2018).
Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager[J]. LSA, 2018,7(2):17152-9. DOI： 10.1038/lsa.2017.152.

Yesilkoy, F. et al. Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager. Light: Science & Applications, 7, 17152 (2018). DOI： 10.1038/lsa.2017.152.

摘要

Abstract

Nanophotonics

and more specifically plasmonics

provides a rich toolbox for biomolecular sensing

since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels. So far

biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity changes. However

the phase response of the plasmonic resonances have rarely been exploited

mainly because this requires a more sophisticated optical arrangement. Here we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by plasmonics. It employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical path configuration. This unique combination allows the detection of atomically thin (angstrom-level) topographical features over large areas

enabling simultaneous reading of thousands of microarray elements. As the plasmonic chips are fabricated using scalable techniques and the imaging reader is built with low-cost off-the-shelf consumer electronic and optical components

the proposed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample volumes. Our research opens new horizons for on-site disease diagnostics and remote health monitoring.

关键词

Keywords

interferometric imaginglabel-free plasmonic biosensorslens-free imagingphase interrogationpoint-of-care devicesprotein microarray detection

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