Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing

Srdjan S Aćimović; Hana Šípová; Gustav Emilsson; Andreas B Dahlin; Tomasz J Antosiewicz; Mikael Käll

doi:10.1038/lsa.2017.42

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Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing

Original Articles

- Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing
- Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing
- LSA 2017年6卷第3期
- Affiliations：
  
  1.Department of Physics, Chalmers University of Technology, 412 96 Göteborg, Sweden
  2.Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Göteborg, Sweden
  3.Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland
- Author bio：
  
  SS Aćimović, Email: srdjan.acimovic@chalmers.se
  M Käll, Email: mikael.kall@chalmers.se
- Funds：
- DOI：10.1038/lsa.2017.42
  中图分类号：
- 纸质出版日期：2017-09，
  
  网络出版日期：2017-03-10，
  
  收稿日期：2016-11-22，
  
  修回日期：2017-03-02，
  
  录用日期：2017-03-08
- Accepted：
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Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing[J]. LSA, 2017,6(3).

Aćimović, S. S. et al. Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing. Light: Science & Applications, 6, e17042 (2017).
Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing[J]. LSA, 2017,6(3). DOI： 10.1038/lsa.2017.42.

Aćimović, S. S. et al. Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing. Light: Science & Applications, 6, e17042 (2017). DOI： 10.1038/lsa.2017.42.

摘要

Abstract

Localized surface plasmon resonance (LSPR) biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization

multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic environment. However

such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption

which must be carefully blocked to avoid compromising the device readings. To address this issue

we made

the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized wet-etching. The resulting LSPR substrate

which consists of gold nanodisks centered on narrow SiO

pillars

exhibits markedly reduced vulnerability to nonspecific substrate adsorption

thus allowing

in an ideal case

the implementation of thicker and more efficient passivation layers. We demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consumption.

关键词

Keywords

biosensinghyperspectrallab-on-a-chipLSPRnonspecific adsorption

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