Localization optoacoustic tomography

X Luís Dean-Ben; Daniel Razansky

doi:10.1038/lsa.2018.4

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Localization optoacoustic tomography

Original Articles

- Localization optoacoustic tomography
- Localization optoacoustic tomography
- LSA 2018年7卷第3期
- Affiliations：
  
  1.Institute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg 85764, Germany
  2.School of Medicine and School of Bioengineering, Technical University of Munich, Munich 81675, Germany
- Author bio：
  
  XL Dean-Ben, Email: xl.deanben@helmholtz-muenchen.de
- Funds：
- DOI：10.1038/lsa.2018.4
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2018-04-20，
  
  收稿日期：2017-08-17，
  
  修回日期：2018-01-12，
  
  录用日期：2018-01-14
- Accepted：
Scan QR Code
Localization optoacoustic tomography[J]. LSA, 2018,7(3):18004-5.

Dean-Ben, X. L.& Razansky, D. et al. Localization optoacoustic tomography. Light: Science & Applications, 3, 18004 (2018).
Localization optoacoustic tomography[J]. LSA, 2018,7(3):18004-5. DOI： 10.1038/lsa.2018.4.

Dean-Ben, X. L.& Razansky, D. et al. Localization optoacoustic tomography. Light: Science & Applications, 3, 18004 (2018). DOI： 10.1038/lsa.2018.4.

摘要

Abstract

Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues. Herein

we introduce a new concept of localization optoacoustic tomography (LOT) that employs rapid sequential acquisition of three-dimensional optoacoustic images from flowing absorbing particles. We show that the new method enables breaking through the spatial resolution barrier of acoustic diffraction while further enhancing the visibility of structures under limited-view tomographic conditions. Given the intrinsic sensitivity of optoacoustics to multiple hemodynamic and oxygenation parameters

LOT may enable a new level of performance in studying functional and anatomical alterations of microcirculation.

关键词

Keywords

acoustic diffractionlimited-view effectslocalizationoptoacoustic imagingphotoacoustic imagingsuper-resolution

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