Color Cherenkov imaging of clinical radiation therapy

Daniel A. Alexander; Anthony Nomezine; Lesley A. Jarvis; David J. Gladstone; Brian W. Pogue; Petr Bruza

doi:10.1038/s41377-021-00660-0

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Color Cherenkov imaging of clinical radiation therapy

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- Color Cherenkov imaging of clinical radiation therapy
- Color Cherenkov imaging of clinical radiation therapy
- LSA 2021年10卷第12期页码：2380-2386
- Affiliations：
  
  1.Thayer School of Engineering, Dartmouth College, Hanover, NH, USA
  2.DoseOptics LLC, Lebanon, NH, USA
  3.Geisel School of Medicine, Dartmouth College, Hanover, NH, USA
  4.Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
- Author bio：
  
  Petr Bruza (Petr.Bruza@dartmouth.edu)
- Funds：
- DOI：10.1038/s41377-021-00660-0
  中图分类号：
- 纸质出版日期：2021-12-31，
  
  网络出版日期：2021-11-04，
  
  收稿日期：2021-07-06，
  
  修回日期：2021-10-01，
  
  录用日期：2021-10-08
- Accepted：
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Color Cherenkov imaging of clinical radiation therapy[J]. LSA, 2021,10(12):2380-2386.

Alexander D. A. et al. Color Cherenkov imaging of clinical radiation therapy. Light: Science & Applications, 10, 2380-2386 (2021).
Color Cherenkov imaging of clinical radiation therapy[J]. LSA, 2021,10(12):2380-2386. DOI： 10.1038/s41377-021-00660-0.

Alexander D. A. et al. Color Cherenkov imaging of clinical radiation therapy. Light: Science & Applications, 10, 2380-2386 (2021). DOI： 10.1038/s41377-021-00660-0.

摘要

Abstract

Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect

and this light is attenuated by tissue features as it leaves the body. In this study

a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume

oxygen saturation and major vessels within the body.

关键词

Keywords

references

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