Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media

Yanyu Zhao; Bowen Song; Ming Wang; Yang Zhao; Yubo Fan

doi:10.1038/s41377-021-00681-9

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Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media

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- Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media
- Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media
- LSA 2021年10卷第12期页码：2518-2530
- Affiliations：
  
  1.Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Engineering Medicine, and with the School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China
  2.Institute of Spacecraft Application System Engineering, China Academy of Space Technology, 100094 Beijing, China
  3.Beijing Institute of Spacecraft Engineering, 100094 Beijing, China
- Author bio：
  
  Yanyu Zhao (yanyuzhao@buaa.edu.cn)
  Yubo Fan (yubofan@buaa.edu.cn)
- Funds：
- DOI：10.1038/s41377-021-00681-9
  中图分类号：
- 纸质出版日期：2021-12-31，
  
  网络出版日期：2021-12-09，
  
  收稿日期：2021-04-30，
  
  修回日期：2021-10-28，
  
  录用日期：2021-11-23
- Accepted：
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Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media[J]. LSA, 2021,10(12):2518-2530.

Zhao, Y. Y. et al. Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media. Light: Science & Applications, 10, 2518-2530 (2021).
Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media[J]. LSA, 2021,10(12):2518-2530. DOI： 10.1038/s41377-021-00681-9.

Zhao, Y. Y. et al. Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media. Light: Science & Applications, 10, 2518-2530 (2021). DOI： 10.1038/s41377-021-00681-9.

摘要

Abstract

The ability to quantify optical properties (i.e.

absorption and scattering) of strongly turbid media has major implications on the characterization of biological tissues

fluid fields

and many others. However

there are few methods that can provide wide-field quantification of optical properties

and none is able to perform quantitative optical property imaging with high-speed (e.g.

kilohertz) capabilities. Here we develop a new imaging modality termed halftone spatial frequency domain imaging (halftone-SFDI)

which is approximately two orders of magnitude faster than the state-of-the-art

and provides kilohertz high-speed

label-free

non-contact

wide-field quantification for the optical properties of strongly turbid media. This method utilizes halftone binary patterned illumination to target the spatial frequency response of turbid media

which is then mapped to optical properties using model-based analysis. We validate the halftone-SFDI on an array of phantoms with a wide range of optical properties as well as in vivo human tissue. We demonstrate with an in vivo rat brain cortex imaging study

and show that halftone-SFDI can longitudinally monitor the absolute concentration as well as spatial distribution of functional chromophores in tissue. We also show that halftone-SFDI can spatially map dual-wavelength optical properties of a highly dynamic flow field at kilohertz speed. Together

these results highlight the potential of halftone-SFDI to enable new capabilities in fundamental research and translational studies including brain science and fluid dynamics.

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