Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy

Yongkang Zhang; Jie Zheng; Fangzhou Jin; Jie Xiao; Ni Lan; Zhiyuan Xu; Xu Yue; Zesen Li; Chengzhi Li; Donglin Cao; Yifei Wang; Wenbin Zhong; Yang Ran; Bai-Ou Guan

doi:10.1038/s41377-024-01586-z

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Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy

Original Articles

- Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy
- Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy
- LSA 2024年13卷第10期页码：2389-2404
- Affiliations：
  
  1.Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou, China
  2.College of Physics & Optoelectronic Engineering, Jinan University, Guangzhou, China
  3.The MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou, China
  4.Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
  5.Department of Laboratory Medicine, the Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China
  6.Department of Interventional Radiology and Vascular Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China
- Author bio：
  
  Yang Ran (tranyang@jnu.edu.cn)
  Bai-Ou Guan (tguanbo@jnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-024-01586-z
  中图分类号：
- 收稿日期：2024-03-02，
  
  修回日期：2024-07-28，
  
  录用日期：2024-08-14，
  
  网络出版日期：2024-09-03，
  
  纸质出版日期：2024-10-31
- Accepted：
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Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy[J]. LSA, 2024,13(10):2389-2404.

Zhang, Y. K. et al. Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy. Light: Science & Applications, 13, 2389-2404 (2024).
Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy[J]. LSA, 2024,13(10):2389-2404. DOI： 10.1038/s41377-024-01586-z.

Zhang, Y. K. et al. Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy. Light: Science & Applications, 13, 2389-2404 (2024). DOI： 10.1038/s41377-024-01586-z.

摘要

Abstract

Chemotherapy is one of the conventional treatments for cancer in clinical practice. However

poor delivery efficiency

systemic toxicity

and the lack of pharmacokinetic monitoring during treatment are the critical limitations of current chemotherapy. Herein

we reported a brand-new antitumor drug delivery strategy that harnesses an optical fiber endoscopically therapeutic probe. The fiber probe carries photosensitizers in the fiber core and antitumor agents on the fiber surface mediated by a temperature-responsive hydrogel film

giving rise to an activable photothermal-chemotherapy that orchestrates the localized hyperthermia and thermal-stimuli drug release to the tumor lesion. Furthermore

the dynamical drug release and in-situ temperature can be real-time supervised through the built-in fiber sensors

including the reflective Mach–Zehnder interferometer and fiber Bragg grating

to visualize the therapy process and thus improve the safety of treatment. Compared with conventional methods

the fiber-optic drug delivery can adequately take advantage of the chemotherapeutics through collaboratively recruiting the photoheating-mediated enhanced permeability and the hydrogel particle-assisted high drug retention

shedding new light on a "central-to-peripheral" drug pervasion and retention mechanism to destroy tumors completely. The fiber-optic chemotherapy strategy incorporates precise drug delivery

accurate controllability of drug release

high drug permeability and retention in tumor

low off-target rate

and real-time drug release and temperature feedback

performing a straightforward and precise photothermal-chemotherapy pathway. More than that

the proposed strategy holds tremendous promise to provide a revolutionized on-demand drug delivery platform for the highly efficient evaluation and screening of antitumor pharmaceuticals.

关键词

Keywords

references

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