Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer

Takeo Minamikawa; Reiko Sakaguchi; Yoshinori Harada; Hiroki Tanioka; Sota Inoue; Hideharu Hase; Yasuo Mori; Tetsuro Takamatsu; Yu Yamasaki; Yukihiro Morimoto; Masahiro Kawasaki; Mitsuo Kawasaki

doi:10.1038/s41377-024-01655-3

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Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer

Original Articles

- Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer
- Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer
- LSA 2024年13卷第12期页码：3158-3170
- Affiliations：
  
  1.Department of Systems Innovation, Graduate School of Engineering Science, Osaka University, Osaka 560-8531, Japan
  2.Division of Interdisciplinary Researches for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima 770-8506, Japan
  3.Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  4.PRESTO, Japan Science and Technology Agency (JST), Tokushima 770-8506, Japan
  5.Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto 606-8501, Japan
  6.Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan
  7.Department of Medical Photonics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  8.Technology and Engineering Division, Ushio Inc., Hyogo 671-0224, Japan
  9.The Institute of Science and Industrial Research, Osaka University, Osaka 567-0047, Japan
  10.Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan
- Author bio：
  
  Takeo Minamikawa (minamikawa.takeo.es@osaka-u.ac.jp)
- Funds：
- DOI：10.1038/s41377-024-01655-3
  中图分类号：
- 收稿日期：2023-11-12，
  
  修回日期：2024-08-26，
  
  录用日期：2024-09-28，
  
  网络出版日期：2024-10-28，
  
  纸质出版日期：2024-12-31
- Accepted：
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Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer[J]. LSA, 2024,13(12):3158-3170.

Minamikawa, T. et al. Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer. Light: Science & Applications, 13, 3158-3170 (2024).
Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer[J]. LSA, 2024,13(12):3158-3170. DOI： 10.1038/s41377-024-01655-3.

Minamikawa, T. et al. Long-range enhancement for fluorescence and Raman spectroscopy using Ag nanoislands protected with column-structured silica overlayer. Light: Science & Applications, 13, 3158-3170 (2024). DOI： 10.1038/s41377-024-01655-3.

摘要

Abstract

We demonstrate long-range enhancement of fluorescence and Raman scattering using a dense random array of Ag nanoislands (AgNIs) coated with column-structured silica (CSS) overlayer of over 100 nm thickness

namely

remote plasmonic-like enhancement (RPE). The CSS layer provides physical and chemical protection

reducin

g the impact between analyte molecules and metal nanostructures. RPE plates are fabricated with high productivity using sputtering and chemical immersion in gold(Ⅰ)/halide solution. The RPE plate significantly enhances Raman scattering and fluorescence

even without proximity between analyte molecules and metal nanostructures. The maximum enhancement factors are 10

-fold for Raman scattering and 10

-fold for fluorescence. RPE is successfully applied to enhance fluorescence biosensing of intracellular signalling dynamics in HeLa cells and Raman histological imaging of oesophagus tissues. Our findings present an interesting deviation from the conventional near-field enhancement theory

as they cannot be readily explained within its framework. However

based on the phenomenological aspects we have demonstrated

the observed enhancement is likely associated with the remote resonant coupling between the localised surface plasmon of AgNIs and the molecular transition dipole of the analyte

facilitated through the CSS structure. Although further investigation is warranted to fully understand the underlying mechanisms

the RPE plate offers practical advantages

such as high productivity and biocompatibility

making it a valuable tool for biosensing and biomolecular analysis in chemistry

biology

and medicine. We anticipate that RPE will advance as a versatile analytical tool for enhanced biosensing using Raman and fluorescence analysis in various biological contexts.

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references

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