Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing

Shaojun Fang; Qiangqiang Zhou; Mengqi Zhou; Changyi Li; Huaxing Xu; Hongyu Tang; Wanlu Zhang; Ruiqian Guo; Xiaoling Wei; Rongjun Zhang

doi:10.1038/s41377-025-01837-7

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Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing

Original Articles

- Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing
- Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing
- LSA 2025年14卷第7期页码：2030-2047
- Affiliations：
  
  1.Department of Optical Science and Engineering, Key Laboratory of Micro and Nano Photonic Structures (MOE), Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, School of Information Science and Technology, Fudan University, Shanghai 200433, China
  2.Department of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai 200001, China
  3.Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai 200001, China
  4.Academy for Engineering and Technology, Fudan University, Shanghai 200433, China
  5.Institute for Electric Light Sources, Fudan University, Shanghai 200433, China
- Author bio：
  
  Xiaoling Wei (xiaoling_wei@fudan.edu.cn)
  Rongjun Zhang (rjzhang@fudan.edu.cn)
- Funds：
- DOI：10.1038/s41377-025-01837-7
  中图分类号：
- 收稿日期：2024-11-24，
  
  修回日期：2025-03-18，
  
  录用日期：2025-03-19，
  
  网络出版日期：2025-05-15，
  
  纸质出版日期：2025-07-31
- Accepted：
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Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing[J]. LSA, 2025,14(7):2030-2047.

Fang, S. J. et al. Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing. Light: Science & Applications, 14, 2030-2047 (2025).
Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing[J]. LSA, 2025,14(7):2030-2047. DOI： 10.1038/s41377-025-01837-7.

Fang, S. J. et al. Dual-step photo-induced self-assembled hydrogel for endogenous oral mucosal wound healing. Light: Science & Applications, 14, 2030-2047 (2025). DOI： 10.1038/s41377-025-01837-7.

摘要

Abstract

By introducing piezoelectric materials into hydrogel oral dressings

a microelectric field could be generated under stress stimulation

thus facilitating oral wound healing. However

to adapt to the moist and dynamic environment of the oral cavity

traditional "step-by-step" synthesis often requires the combination of materials with different functionalities. Given the property differences between these materials

this strategy typically involves complex experimental procedures and unnecessary energy consumption. In this study

with the concept of "integrated construction"

we innovatively proposed a dual-step photo-induced method and successfully fabricated composite hydrogels with excellent performance. We introduced abundant oxygen vacancies into ZnO

leveraging the enhanced interface dynamics to achieve sustained photo-induced effect. With a double-network polymer framework as a template

this method could achieve the photo-induced spontaneous in-situ synthesis of polydopamine (PDA) within hydrogel without any extra special experimental conditions and complex operation procedures. We conducted a thorough analysis of the mechanism underlying this photo-induced method and applied the as-prepared hydrogel for the treatment of oral wounds

which significantly accelerated the healing process due to the outstanding comprehensive performance of hydrogel. These results suggest novel ideas and theoretical support for the facile construction of high-performance hydrogels based on photodynamic principles

demonstrating immense potential for future applications in wound dressings.

关键词

Keywords

references

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