Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis

Danheng Gao; Jiahao Liu; Xiao Liu; Kang He; Zhanyu Ma; Huan Liu; Jihou Wang; Qihan Zhang; Zhaonan Huang; Meng Luo; Haoran Meng; Rui Du; Juntao Gao; Qing Wu; Xinghua Yang

doi:10.1038/s41377-025-01989-6

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Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis

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- Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis
- Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis
- Light: Science & Applications 2025年14卷第12期页码：3875-3901
- Affiliations：
  
  1.State Key Laboratory of Advanced Manufacturing for Optical Systems, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, 130033, China
  2.Division of Thyroid Surgery, The China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun, 130033, China
  3.School of Basic Medical Sciences Tsinghua University Biomedicine Hall, Beijing, 100084, China
  4.Heilongjiang Province Key Laboratory of Laser Spectroscopy Technology and Application, Harbin University of Science and Technology, Harbin, 150080, China
  5.Key Laboratory of In-Fiber Integrated Optics, Ministry of Education, College of Science, Harbin Engineering University, Harbin, 150001, China
- Author bio：
  
  Meng Luo (luomeng@ciomp.ac.cn)
  Haoran Meng (menghaoran@ciomp.ac.cn)
- Funds：
- DOI：10.1038/s41377-025-01989-6
  中图分类号：
- 收稿：2024-12-15，
  
  修回：2025-06-24，
  
  录用：2025-07-25，
  
  网络出版：2025-11-26，
  
  纸质出版：2025-12-31
- Accepted：
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Danheng Gao, Jiahao Liu, Xiao Liu, 等. Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis[J]. Light: Science & Applications, 2025,14(12):3875-3901.

Gao, D. H. et al. Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis. Light: Science & Applications, 14, 3875-3901 (2025).
Danheng Gao, Jiahao Liu, Xiao Liu, 等. Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis[J]. Light: Science & Applications, 2025,14(12):3875-3901. DOI： 10.1038/s41377-025-01989-6.

Gao, D. H. et al. Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis. Light: Science & Applications, 14, 3875-3901 (2025). DOI： 10.1038/s41377-025-01989-6.

摘要

Abstract

Surface-Enhanced Raman Scattering (SERS) integrated with optical waveguide sensing offers a transformative approach to overcoming the limitations of conventional SERS techniques

such as complex alignment requirements and limited signal collection efficiency. By leveraging the unique properties of optical waveguides

this integration significantly enhances detection sensitivity

simplifies sensor design

and enables the analysis of ultra-low concentration analytes in trace-volume samples. This review explores the latest advancements in combining diverse optical waveguide architectures with SERS technology

focusing on strategies to optimize the sensing interface and SERS substrate design for maximal Raman signal enhancement. By enabling efficient analyte excitation and enhanced scattered signal collection through waveguide-mediated light-matter interactions

this approach unlocks new possibilities for high-sensitivity Raman detection. Furthermore

we discuss the potential of this integration to drive breakthroughs in fields such as biomedical diagnostics

environmental monitoring

and chemical sensing

paving the way for next-generation

portable and ultra-sensitive sensing platforms.

关键词

Keywords

references

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