Flexible, stretchable, on-chip optical tweezers for high-throughput bioparticle manipulation

Ziyi He; Jianyun Xiong; Yang Shi; Ting Pan; Shaobiao Chen; Xin Zhang; Yizhen Chen; Xiangxian Wang; Baojun Li; Hongbao Xin

doi:10.1038/s41377-026-02199-4

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Flexible, stretchable, on-chip optical tweezers for high-throughput bioparticle manipulation

Original Articles

- Flexible, stretchable, on-chip optical tweezers for high-throughput bioparticle manipulation
- Flexible, stretchable, on-chip optical tweezers for high-throughput bioparticle manipulation
- Light: Science & Applications 2026年15卷第3期页码：716-727
- Affiliations：
  
  1.Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Institute of Nanophotonics, College of Physics & Optoelectronic Engineering, Jinan University, Guangzhou, China
  2.School of Science, Lanzhou University of Technology, Lanzhou, China
- Author bio：
  
  Baojun Li (baojunli@jnu.edu.cn)
  Hongbao Xin (hongbaoxin@jnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-026-02199-4
  中图分类号：
- 收稿：2025-09-23，
  
  修回：2026-01-08，
  
  录用：2026-01-14，
  
  网络首发：2026-02-03，
  
  纸质出版：2026-03-31
- Accepted：
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Ziyi He, Jianyun Xiong, Yang Shi, 等. Flexible, stretchable, on-chip optical tweezers for high-throughput bioparticle manipulation[J]. Light: Science & Applications, 2026,15(3):716-727.

He, Z. Y., Xiong, J. Y., Shi, Y. et al. Flexible, stretchable, on-chip optical tweezers for high-throughput bioparticle manipulation. Light: Science & Applications, 15, 716-727 (2026).
Ziyi He, Jianyun Xiong, Yang Shi, 等. Flexible, stretchable, on-chip optical tweezers for high-throughput bioparticle manipulation[J]. Light: Science & Applications, 2026,15(3):716-727. DOI： 10.1038/s41377-026-02199-4.

He, Z. Y., Xiong, J. Y., Shi, Y. et al. Flexible, stretchable, on-chip optical tweezers for high-throughput bioparticle manipulation. Light: Science & Applications, 15, 716-727 (2026). DOI： 10.1038/s41377-026-02199-4.

摘要

Abstract

High-throughput trapping and precision manipulation of individual pathogenic bioparticles in complex microenvironments are of great importance for in-vitro diagnostics and drug screening. Although optical tweezers have been widely used for bioparticle trapping and manipulation

the throughput

functionality

and adaptability are still limited for on-chip integrated bioparticle manipulation in complex and dynamic bioenvironments. Here

we report flexible

stretchable

on-chip optical tweezers (FSOT) based on large-scale orderly assembled microlenses for high-throughput manipulation of bioparticles in complex bio-environments and on flexible substrates

including soft bio-substrates such as skin and intestines. Large-scale (up to 1000) photonic nanojet effect of the microlenses enables high-throughput trapping

sorting

and modulation of individual bioparticles with sizes ranging from sub-100 nm to tens of micrometers

such as exosomes

bacteria and mammalian cells. Our FSOT exhibits high flexibility

which enables bioparticle trapping and sorting in complex and curved biological microenvironments. Importantly

our FSOT also exhibits high deformability and stretchability

which facilitates the control of inter-cellular distance between trapped neighboring cells

enabling real-time modulating and monitoring the interaction between single pathogenic bacteria and macrophage. Our FSOT represents a new class of on-chip optical tweezers for high-throughput bioparticle trapping and manipulation with the features of high flexibility and stretchability

and holds great promises as an integrated on-chip platform for high-throughput dynamic analysis of bioparticles

for revealing inter-cellular interactions between pathogenic bioparticles and host cells

and for precise drug screening.

关键词

Keywords

references

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