Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions

Rekha Gautam; Yinxiao Xiang; Josh Lamstein; Yi Liang; Anna Bezryadina; Guo Liang; Tobias Hansson; Benjamin Wetzel; Daryl Preece; Adam White; Matthew Silverman; Susan Kazarian; Jingjun Xu; Roberto Morandotti; Zhigang Chen

doi:10.1038/s41377-019-0142-1

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Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions

Articles

- Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions
- Light: Science & Applications Vol. 8, Issue 2, Pages: 279-287(2019)
- Affiliations：
  
  1.Department of Physics and Astronomy, San Francisco State University, San Francisco, CA, 94132, USA
  2.Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37240, USA
  3.MOE Key Lab of Weak-Light Nonlinear Photonics, TEDA Applied Physics Institute and School of Physics, Nankai University, Tianjin, 300457, China
  4.Guangxi Key Lab for Relativistic Astrophysics, Guangxi Colleges and Universities Key Lab of Novel Energy Materials and Related Technology, School of Physical Science and Technology, Guangxi University, Nanning, Guangxi, 530004, China
  5.Department of Physics and Astronomy, California State University Northridge, Northridge, CA, 91330, USA
  6.Institut National de la Recherche Scientifique, Université du Québec, Varennes, QC, J3X 1S2, Canada
  7.Department of Physics, Chemistry and Biology, Linköping University, Linköping, SE-581 83, Sweden
  8.School of Mathematical and Physical Sciences, University of Sussex, Sussex House, Falmer, Brighton, BN1 9RH, UK
  9.Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA
  10.Clinical Laboratory Science Program, San Francisco State University, San Francisco, CA, 94132, USA
  11.Institute of Fundamental and Frontier Sciences, University of Electronic Science and Tech. of China, Chengdu, 610054, China
  12.ITMO University, Saint Petersburg, 197101, Russia
- Author bio：
  
  Yinxiao Xiang (yinxiaoermao@nankai.edu.cn)
  Yinxiao Xiang (yinxiaoermao@nankai.edu.cn)
- Funds：
- DOI：10.1038/s41377-019-0142-1
  CLC：
- Published：2019，
  
  Published Online：13 March 2019，
  
  Received：02 October 2018，
  
  Revised：21 February 2019，
  
  Accepted：22 February 2019
- Accepted：
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Gautam, R. et al. Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions. Light: Science & Applications, 8, 279-287 (2019).
DOI：

Gautam, R. et al. Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions. Light: Science & Applications, 8, 279-287 (2019). DOI： 10.1038/s41377-019-0142-1.

摘要

Abstract

Osmotic conditions play an important role in the cell properties of human red blood cells (RBCs)

which are crucial for the pathological analysis of some blood diseases such as malaria. Over the past decades

numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes. Here

we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions. Specifically

we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions

where the strength of the optical nonlinearity increases with osmotic pressure on the cells. This tunable nonlinearity is attributed to optical forces

particularly the forward-scattering and gradient forces. Interestingly

in aged blood samples (with lysed cells)

a notably different nonlinear behavior is observed due to the presence of free hemoglobin. We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations. Our work on light self-guiding through scattering bio-soft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis.

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