Single-cell biomagnifier for optical nanoscopes and nanotweezers

Yuchao Li; Xiaoshuai Liu; Baojun Li

doi:10.1038/s41377-019-0168-4

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Single-cell biomagnifier for optical nanoscopes and nanotweezers

Article

- Single-cell biomagnifier for optical nanoscopes and nanotweezers
- Light: Science & Applications Vol. 8, Issue 6, Pages: 966-977(2019)
- Affiliations：
  
  Institute of Nanophotonics, Jinan University, 511443 Guangzhou, China
- Author bio：
  
  Baojun Li (baojunli@jnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-019-0168-4
  CLC：
- Published：2019，
  
  Published Online：03 July 2019，
  
  Received：27 January 2019，
  
  Revised：30 May 2019，
  
  Accepted：02 June 2019
- Accepted：
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Li, Y. C., Liu, X. S. & Li, B. J. Single-cell biomagnifier for optical nanoscopes and nanotweezers. Light: Science & Applications, 8, 966-977 (2019).
DOI：

Li, Y. C., Liu, X. S. & Li, B. J. Single-cell biomagnifier for optical nanoscopes and nanotweezers. Light: Science & Applications, 8, 966-977 (2019). DOI： 10.1038/s41377-019-0168-4.

摘要

Abstract

Optical microscopes and optical tweezers

which were invented to image and manipulate microscale objects

have revolutionize

d cellular and molecular biology. However

the optical resolution is hampered by the diffraction limit; thus

optical microscopes and optical tweezers cannot be directly used to image and manipulate nano-objects. The emerging plasmonic/photonic nanoscopes and nanotweezers can achieve nanometer resolution

but the high-index material structures will easily cause mechanical and photothermal damage to biospecimens. Here

we demonstrate subdiffraction-limit imaging and manipulation of nano-objects by a noninvasive device that was constructed by trapping a cell on a fiber tip. The trapped cell

acting as a biomagnifier

could magnify nanostructures with a resolution of 100 nm (

/5.5) under white-light microscopy. The focus of the biomagnifier formed a nano-optical trap that allowed precise manipulation of an individual nanoparticle with a radius of 50 nm. This biomagnifier provides a high-precision tool for optical imaging

sensing

and assembly of bionanomaterials.

关键词

Keywords

references

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