Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography

Kausik Basak; Xosé Luís Deán-Ben; Sven Gottschalk; Michael Reiss; Daniel Razansky

doi:10.1038/s41377-019-0181-7

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Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography

Article

- Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography
- Light: Science & Applications Vol. 8, Issue 4, Pages: 610-619(2019)
- Affiliations：
  
  1.Faculty of Medicine, Technical University Munich, Munich, Germany
  2.Institute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany
  3.Faculty of Medicine and Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
  4.Institute for Biomedical Engineering and Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich, Switzerland
  5.Present address: Kausik Basak, Institute of Advanced Studies and Research, JIS University, Kolkata, West Bengal, India
- Author bio：
  
  Daniel Razansky (daniel.razansky@uzh.ch)
- Funds：
- DOI：10.1038/s41377-019-0181-7
  CLC：
- Published：2019，
  
  Published Online：14 August 2019，
  
  Received：19 February 2019，
  
  Revised：27 June 2019，
  
  Accepted：17 July 2019
- Accepted：
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Basak, K. et al. Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography. Light: Science & Applications, 8, 610-619 (2019).
DOI：

Basak, K. et al. Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography. Light: Science & Applications, 8, 610-619 (2019). DOI： 10.1038/s41377-019-0181-7.

摘要

Abstract

Despite the importance of placental function in embryonic development

it remains poorly understood and challenging to characterize

primarily due to the lack of non-invasive imaging tools capable of monitoring placental and foetal oxygenation and perfusion parameters during pregnancy. We developed an optoacoustic tomography approach for real-time imaging through entire ~4 cm cross-sections of pregnant mice. Functional changes in both maternal and embryo regions were studied at different gestation days when subjected to an oxygen breathing challenge and perfusion with indocyanine green. Structural phenotyping of the cross-sectional scans highlighted different internal organs

whereas multi-wavelength acquisitions enabled non-invasive label-free spectroscopic assessment of blood-oxygenation parameters in foeto-placental regions

rendering a strong correlation with the amount of oxygen administered. Likewise

the placental function in protecting the embryo from extrinsically administered agents was substantiated. The proposed methodology may potentially further serve as a probing mechanism to appraise embryo development during pregnancy in the clinical setting.

关键词

Keywords

references

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