Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity

Zhongxu Cao; Baicheng Yao; Chenye Qin; Run Yang; Yanhong Guo; Yufeng Zhang; Yu Wu; Lei Bi; Yuanfu Chen; Zhenda Xie; Gangding Peng; Shu-Wei Huang; Chee Wei Wong; Yunjiang Rao

doi:10.1038/s41377-019-0213-3

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Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity

Letter

- Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity
- Light: Science & Applications Vol. 8, Issue 6, Pages: 934-943(2019)
- Affiliations：
  
  1.Key Laboratory of Optical Fiber Sensing and Communications (Education Ministry of China), University of Electronic Science and Technology of China, Chengdu 611731, China
  2.State Key Lab of Electronic Thin Film and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 611731, China
  3.National Laboratory of Solid State Microstructures and School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China
  4.School of Electrical Engineering and Telecommunications, University of New South Wales, Sydney, NSW 2052, Australia
  5.Department of Electrical, Computer, and Energy Engineering, University of Colorado Boulder, Boulder, CO 80309, USA
  6.Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory, University of California, Los Angeles, CA 90095, USA
  7.Ubiquitous Sensing Center, Zhejiang Laboratory, Hangzhou 310000, China
- Author bio：
  
  Baicheng Yao (yaobaicheng@uestc.edu.cn)
  CheeWei Wong (cheewei.wong@ucla.edu)
  Yunjiang Rao (yjrao@uestc.edu.cn)
- Funds：
- DOI：10.1038/s41377-019-0213-3
  CLC：
- Published：2019，
  
  Published Online：22 November 2019，
  
  Received：13 June 2019，
  
  Revised：22 October 2019，
  
  Accepted：26 October 2019
- Accepted：
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Cao, Z. X. et al. Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity. Light: Science & Applications, 8, 934-943 (2019).
DOI：

Cao, Z. X. et al. Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity. Light: Science & Applications, 8, 934-943 (2019). DOI： 10.1038/s41377-019-0213-3.

摘要

Abstract

Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis. The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity. As atomically thick films with remarkable optoelectronic tunability

graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing

thus enabling significant performance enhancement

versatile functionalization and flexible device integration. Here

we demonstrate a partially reduced graphene oxide (

prGO

) inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection. Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer (FRET) to be chemically selective in the visible band. Moreover

by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision

we achieved individual molecule sensitivity for dopamine

nicotine and single-strand DNA detection. This work combines atomic-layer nanoscience and high-resolution optoelectronics

providing a way toward high-performance biochemical sensors and systems.

关键词

Keywords

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