Full noncontact laser ultrasound: first human data

Xiang Zhang; Jonathan R. Fincke; Charles M. Wynn; Matt R. Johnson; Robert W. Haupt; Brian W. Anthony

doi:10.1038/s41377-019-0229-8

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Full noncontact laser ultrasound: first human data

Article

- Full noncontact laser ultrasound: first human data
- Light: Science & Applications Vol. 8, Issue 6, Pages: 1198-1208(2019)
- Affiliations：
  
  1.Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA
  2.Institute for Medical Engineering & Science, Massachusetts Institute of Technology, 45 Carleton St., Cambridge, MA 02142, USA
  3.Lincoln Laboratory, Massachusetts Institute of Technology, 244 Wood Street, Lexington, MA 02421, USA
- Author bio：
  
  Xiang Zhang (xzhang88@mit.edu)
  Brian W. Anthony (banthony@mit.edu)
- Funds：
- DOI：10.1038/s41377-019-0229-8
  CLC：
- Published：2019，
  
  Published Online：20 December 2019，
  
  Received：20 June 2019，
  
  Revised：25 November 2019，
  
  Accepted：27 November 2019
- Accepted：
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Zhang, X. et al. Full noncontact laser ultrasound: first human data. Light: Science & Applications, 8, 1198-1208 (2019).
DOI：

Zhang, X. et al. Full noncontact laser ultrasound: first human data. Light: Science & Applications, 8, 1198-1208 (2019). DOI： 10.1038/s41377-019-0229-8.

摘要

Abstract

Full noncontact laser ultrasound (LUS) imaging has several distinct advantages over current medical ultrasound (US) technologies: elimination of the coupling mediums (gel/water)

operator-independent image quality

improved repeatability

and volumetric imaging. Current light-based ultrasound utilizing tissue-penetrating photoacoustics (PA) generally uses traditional piezoelectric transducers in contact with the imaged tissue or carries an optical fiber detector close to the imaging site. Unlike PA

the LUS design presented here minimizes the optical penetration and specifically restricts optical-to-acoustic energy transduction at the tissue surface

maximizing the generated acoustic source amplitude. With an appropriate optical design and interferometry

any exposed tissue surfaces can become viable acoustic sources and detectors. LUS operates analogously to conventional ultrasound but uses light instead of piezoelectric elements. Here

we present full noncontact LUS results

imaging targets at ~5 cm depths and at a meter-scale standoff from the target surface. Experimental results demonstrating volumetric imaging and the first LUS images on humans are presented

all at eye- and skin-safe optical exposure levels. The progression of LUS imaging from tissue-mimicking phantoms

to excised animal tissue

to humans in vivo is shown

with validation from conventional ultrasound images. The LUS system design insights and results presented here inspire further LUS development and are a significant step toward the clinical implementation of LUS.

关键词

Keywords

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