Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use

Jiawen Li; Simon Thiele; Bryden C. Quirk; Rodney W. Kirk; Johan W. Verjans; Emma Akers; Christina A. Bursill; Stephen J. Nicholls; Alois M. Herkommer; Harald Giessen; Robert A. McLaughlin

doi:10.1038/s41377-020-00365-w

Go to Nature Website

Your Location：

Home >

Browse articles >

Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use

Article

- Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use
- Light: Science & Applications Vol. 9, Issue 4, Pages: 1208-1217(2020)
- Affiliations：
  
  1.Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia
  2.Institute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide, SA 5005, Australia
  3.Institute of Applied Optics (ITO) and Research Center SCoPE, University of Stuttgart, 70569 Stuttgart, Germany
  4.South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA 5000, Australia
  5.Royal Adelaide Hospital, Adelaide, SA 5000, Australia
  6.Monash Cardiovascular Research Centre, Monash University, Melbourne, VIC 3168, Australia
  7.4th Physics Institute and Research Center SCoPE, University of Stuttgart, 70569 Stuttgart, Germany
- Author bio：
  
  Jiawen Li (jiawen.li01@adelaide.edu.au)
- Funds：
- DOI：10.1038/s41377-020-00365-w
  CLC：
- Published：2020，
  
  Published Online：20 July 2020，
  
  Received：16 February 2020，
  
  Revised：23 June 2020，
  
  Accepted：04 July 2020
- Accepted：
Scan QR Code
Li, J. W. et al. Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use. Light: Science & Applications, 9, 1208-1217 (2020).
DOI：

Li, J. W. et al. Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use. Light: Science & Applications, 9, 1208-1217 (2020). DOI： 10.1038/s41377-020-00365-w.

摘要

Abstract

Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via endoscopes. Miniaturized endoscopic probes are necessary for imaging small luminal or delicate organs without causing trauma to tissue. However

current fabrication methods limit the imaging performance of highly miniaturized probes

restricting their widespread application. To overcome this limitation

we developed a novel ultrathin probe fabrication technique that utilizes 3D microprinting to reliably create side-facing freeform micro-optics (< 130 µm diameter) on single-mode fibers. Using this technique

we built a fully functional ultrathin aberration-corrected optical coherence tomography probe. This is the smallest freeform 3D imaging probe yet reported

with a diameter of 0.457 mm

including the catheter sheath. We demonstrated image quality and mechanical flexibility by imaging atherosclerotic human and mouse arteries. The ability to provide microstructural information with the smallest optical coherence tomography catheter opens a gateway for novel minimally invasive applications in disease.

关键词

Keywords

references

Bouma, B. E. et al. Intravascular optical coherence tomography [Invited].Biomed. Opt. Express8, 2660–2686 (2017)..

Gora, M. J. et al. Endoscopic optical coherence tomography: technologies and clinical applications [Invited].Biomed. Opt. Express8, 2405–2444 (2017)..

Li, J. W. et al. Perspective: biomedical sensing and imaging with optical fibers—innovation through convergence of science disciplines.APL Photonics3, 100902 (2018)..

Yamaguchi, T. et al. Safety and feasibility of an intravascular optical coherence tomography image wire system in the clinical setting.Am. J. Cardiol.101, 562–567 (2008)..

Swanson, E. A.&Fujimoto, J. G. The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact [Invited].Biomed. Opt. Express8, 1638–1664 (2017)..

Hanna, N. et al. Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura.J. Thorac. Cardiovasc. Surg.129, 615–622 (2005)..

Tahara, S. et al. Intravascular optical coherence tomography detection of atherosclerosis and inflammation in murine aorta.Arterioscler. Thromb. Vasc. Biol.32, 1150–1157 (2012)..

Yuan, W. et al. Super-achromatic monolithic microprobe for ultrahigh-resolution endoscopic optical coherence tomography at 800 nm.Nat. Commun.8, 1531 (2017)..

Scolaro, L. et al. High-sensitivity anastigmatic imaging needle for optical coherence tomography.Opt. Lett.37, 5247–5249 (2012)..

Pahlevaninezhad, H. et al. Nano-optic endoscope for high-resolution optical coherence tomography in vivo.Nat. Photonics12, 540–547 (2018)..

Kim, J. et al. Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter.Opt. Lett.42, 379–382 (2017)..

Yin, B. W. et al. Extended depth of focus for coherence-based cellular imaging.Optica4, 959–965 (2017)..

Htun, N. M. et al. Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques.Nat. Commun.8, 75 (2017)..

Quirk, B. C. et al. In situ imaging of lung alveoli with an optical coherence tomography needle probe.J. Biomed. Opt.16, 036009 (2011)..

Liu, L. B. et al. Imaging the subcellular structure of human coronary atherosclerosis using micro–optical coherence tomography.Nat. Med.17, 1010–1014 (2011)..

Nishimura, S. et al. Cholesterol crystal as a new feature of coronary vulnerable plaques: an optical coherence tomography study.J. Cardiol.69, 253–259 (2017)..

Luo, Y. M. et al. Imaging cellular structures of atherosclerotic coronary arteries using circumferentially scanning micro-optical coherence tomography fiber probe ex vivo.IEEE Access6, 62988–62994 (2018)..

Benalcazar, W. A., Jung, W.&Boppart, S. A. Aberration characterization for the optimal design of high-resolution endoscopic optical coherence tomography catheters.Opt. Lett.37, 1100–1102 (2012)..

Tan, K. M. et al. Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance.Biomed. Opt. Express3, 1947–1954 (2012)..

Lorenser, D. et al. Ultrathin side-viewing needle probe for optical coherence tomography.Opt. Lett.36, 3894–3896 (2011)..

Malinauskas, M. et al. Ultrafast laser nanostructuring of photopolymers: a decade of advances.Phys. Rep.533, 1–31 (2013)..

Von Freymann, G. et al. Three‐dimensional nanostructures for photonics.Adv. Funct. Mater.20, 1038–1052 (2010)..

Sun, H. B.&Kawata, S. Two-photon photopolymerization and 3D lithographic microfabrication. in NMR• 3D Analysis• Photopolymerization (Fatkullin, N. eds et al.) 169–273 (Berlin, Heidelberg: Springer, 2004).

Lightman, S. et al. Miniature wide-spectrum mode sorter for vortex beams produced by 3D laser printing.Optica4, 605–610 (2017)..

Malinauskas, M. et al. Femtosecond laser polymerization of hybrid/integrated micro-optical elements and their characterization.J. Opt.12, 124010 (2010)..

Lightman, S. et al. Shaping of light beams by 3D direct laser writing on facets of nonlinear crystals.Opt. Lett.40, 4460–4463 (2015)..

Wu, D. et al. High numerical aperture microlens arrays of close packing.Appl. Phys. Lett.97, 031109 (2010)..

Li, J. et al. Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes.Sci. Rep.8, 14789 (2018)..

Lorenser, D., Yang, X. J.&Sampson, D. D. Ultrathin fiber probes with extended depth of focus for optical coherence tomography.Opt. Lett.37, 1616–1618 (2012)..

Gissibl, T. et al. Two-photon direct laser writing of ultracompact multi-lens objectives.Nat. Photonics10, 554–560 (2016)..

Narula, J.&Strauss, H. W. The popcorn plaques.Nat. Med.13, 532–534 (2007)..

Robinson, S. T.&Taylor, W. R. Beyond the adventitia: exploring the outer limits of the blood vessel wall.Circ. Res.104, 416–418 (2009)..

Fleg, J. L. et al. Detection of high-risk atherosclerotic plaque: report of the NHLBI Working Group on current status and future directions.JACC Cardiovasc Imag.5, 941–955 (2012)..

Abela, G. S. et al. Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes.Am. J. Cardiol.103, 959–968 (2009)..

Gissibl, T., Schmid, M.&Giessen, H. Spatial beam intensity shaping using phase masks on single-mode optical fibers fabricated by femtosecond direct laser writing.Optica3, 448–451 (2016)..

Gounis, M. J. et al. Intravascular optical coherence tomography for neurointerventional surgery.Stroke50, 218–223 (2019)..

Mathews, M. S. et al. Neuroendovascular optical coherence tomography imaging and histological analysis.Neurosurgery69, 430–439 (2011)..

Tearney, G. J. et al. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation.J. Am. Coll. Cardiol.59, 1058–1072 (2012)..

van Soest, G. et al. Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging.J. Biomed. Opt.15, 011105 (2010)..

Roberts, A. M.&Grimes, A. L. Enlargement of internal carotid artery aneurysm presenting with severe visual sequela: a case report and anatomy review.Optom. J. Am. Optometric Assoc.80, 76–82 (2009)..

Hariri, L. P. et al. In vivo optical coherence tomography: the role of the pathologist.Arch. Pathol. Lab. Med.136, 1492–1501 (2012)..

Iyer, J. S. et al. Micro-optical coherence tomography of the mammalian cochlea.Sci. Rep.6, 33288 (2016)..

Akhoundi, F. et al. Compact fiber-based multi-photon endoscope working at 1700 nm.Biomed. Opt. Express9, 2326–2335 (2018)..

Zhao, Y. et al. Design of a fiber-optic multiphoton microscopy handheld probe.Biomed. Opt. Express7, 3425–3437 (2016)..

Wang, W. et al. Miniature all-fiber axicon probe with extended Bessel focus for optical coherence tomography.Opt. Express27, 358–366 (2019)..

Tan, K. M. et al. In-fiber common-path optical coherence tomography using a conical-tip fiber.Opt. Express17, 2375–2384 (2009)..

Kowalczyk, M., Haberko, J.&Wasylczyk, P. Microstructured gradient-index antireflective coating fabricated on a fiber tip with direct laser writing.Opt. Express22, 12545–12550 (2014)..

Mayer, F. et al. Multimaterial 3D laser microprinting using an integrated microfluidic system.Sci. Adv.5, eaau9160 (2019)..

Gießen, H., Thiel, M.&Gissibl, T. Method and device for producing microstructures on optical fibers. WO2017059960A1WIPO (PCT) (2018).

Gissibl, T. 3D printing of sub-micrometer accurate ultra-compact free-form optics, PhD Dissertation, University of Stuttgart (2016).

Gissibl, T. et al. Sub-micrometre accurate free-form optics by three-dimensional printing on single-mode fibres.Nat. Commun.7, 11763 (2016)..

Schmid, M., Ludescher, D.&Giessen, H. Optical properties of photoresists for femtosecond 3D printing: refractive index, extinction, luminescence-dose dependence, aging, heat treatment and comparison between 1-photon and 2-photon exposure.Opt. Mater. Express9, 4564–4577 (2019)..

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰